Sex hormone binding globulin and verbal memory in older men

Yoichiro Takayanagi, Adam P Spira, Roger S. McIntyre, William W Eaton

Research output: Contribution to journalArticle

Abstract

Objective Cognitive function in older adults may be affected by multiple factors, such as sex hormone levels, metabolic disturbances, and neuropsychiatric illness. However, relatively few studies have tested the associations between these factors and cognitive function in a single sample. A cross-sectional analysis was conducted to examine the association between sex hormones, metabolic parameters, and psychiatric diagnoses with verbal memory in nondemented older men. Methods Participants were 112 men (mean age: 61.3 years) from the Baltimore Epidemiologic Catchment Area Follow-Up Study who completed measures of blood sex hormone levels, metabolic parameters (e.g., lipid profiles), and verbal memory. Results Higher levels of serum sex hormone binding globulin (SHBG) were associated with lower delayed verbal memory scores (standardized coefficients [beta] =-0.19, t =-2.07, df = 1, 105, p = 0.04), and higher body mass index (BMI) was associated with better immediate (beta = 0.21, t = 2.41, df = 1,105, p = 0.02) and delayed (beta = 0.22, t = 2.46, df = 1,105, p = 0.02) verbal memory performance after adjustment for age, education, and psychiatric disorders. There was an inverse correlation between SHBG levels and BMI (Pearson's r =-0.37, N = 112, p

Original languageEnglish (US)
Pages (from-to)253-260
Number of pages8
JournalAmerican Journal of Geriatric Psychiatry
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2015

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Sex Hormone-Binding Globulin
Gonadal Steroid Hormones
Cognition
Body Mass Index
Repression (Psychology)
Serum Globulins
Baltimore
Mental Disorders
Psychiatry
Cross-Sectional Studies
Lipids
Education

Keywords

  • cognitive function
  • obesity
  • Sex hormone binding globulin
  • sex hormones

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Sex hormone binding globulin and verbal memory in older men. / Takayanagi, Yoichiro; Spira, Adam P; McIntyre, Roger S.; Eaton, William W.

In: American Journal of Geriatric Psychiatry, Vol. 23, No. 3, 01.03.2015, p. 253-260.

Research output: Contribution to journalArticle

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