Sex differences in the treatment and outcomes of patients hospitalized with ST-elevation myocardial infarction

Edward L. Hannan, Yifeng Wu, Jacqueline Tamis-Holland, Alice K. Jacobs, Peter B. Berger, Frederick S.K. Ling, Gary Walford, Ferdinand J. Venditti, Spencer B. King

Research output: Contribution to journalArticle

Abstract

Objectives: To compare mortality for women and men hospitalized with ST-elevation myocardial infarction (STEMI) by age and revascularization status. Background: There is little information on the mortality of men and women not undergoing revascularization, and the impact of age on relative male–female mortality needs to be revisited. Methods and results: An observational database of 23,809 patients with STEMI presenting at nonfederal New York State hospitals between 2013 and 2015 was used to compare risk-adjusted inhospital/30-day mortality for women and men and to explore the impact of age on those differences. Women had significantly higher mortality than men overall (adjusted odds ratio [AOR] = 1.15, 95% CI [1.04, 1.28]), and among patients aged 65 and older. Women had lower revascularization rates in general (AOR = 0.64 [0.59, 0.69]) and for all age groups. Among revascularized STEMI patients, women overall (AOR = 1.30 [1.10, 1.53]) and over 65 had higher mortality than men. Among patients not revascularized, women between the ages of 45 and 64 had lower mortality (AOR = 0.68 [0.48, 0.97]). Conclusions: Women with STEMI, and especially older women, had higher inhospital/30-day mortality rates than their male counterparts. Women had higher mortality among revascularized patients, but not among patients who were not revascularized.

Original languageEnglish (US)
Pages (from-to)196-204
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume95
Issue number2
DOIs
StatePublished - Feb 1 2020

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Keywords

  • ST-elevation myocardial infarction
  • mortality
  • myocardial infarction
  • revascularization
  • sex differences

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hannan, E. L., Wu, Y., Tamis-Holland, J., Jacobs, A. K., Berger, P. B., Ling, F. S. K., Walford, G., Venditti, F. J., & King, S. B. (2020). Sex differences in the treatment and outcomes of patients hospitalized with ST-elevation myocardial infarction. Catheterization and Cardiovascular Interventions, 95(2), 196-204. https://doi.org/10.1002/ccd.28286