Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer’s Disease

Ye Tao, Matthew Peters, Lea T. Drye, Davangere P. Devanand, Jacobo E. Mintzer, Bruce G. Pollock, Anton P. Porsteinsson, Paul B Rosenberg, Lon S. Schneider, Dave Shade, Daniel Weintraub, Jerome Yesavage, Constantine G Lyketsos, Cynthia Munro, the CitAD Research Group for the CitAD Research Group

Research output: Contribution to journalArticle


The aim of this study was to describe sex differences in neuropsychiatric symptoms (NPSs) in patients with Alzheimer’s disease (AD). Baseline scores on the Cohen-Mansfield Agitation Inventory, Neurobehavioral Rating Scale–Agitation subscale, and the Neuropsychiatric Inventory from patients with AD enrolled in a multicenter trial of citalopram for the treatment of agitation were analyzed. We found not only that patients with AD having agitation were likely to exhibit many other NPSs but also that the women in this study were more likely to exhibit a broader range of NPS than were the men. These results suggest greater heterogeneity in the clinical presentation of women compared to men, and thus in the potential targets for treatment in these patients. Further characterization of sex differences in NPS can inform future efforts aimed at establishing subtypes of patients for whom various treatment approaches will be most appropriate.

Original languageEnglish (US)
JournalAmerican Journal of Alzheimer's Disease and other Dementias
StateAccepted/In press - Jan 1 2018



  • agitation
  • Alzheimer disease
  • behavioral disturbance
  • gender difference
  • neuropsychiatric

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Tao, Y., Peters, M., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G., Munro, C., & for the CitAD Research Group, T. CD. R. G. (Accepted/In press). Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer’s Disease. American Journal of Alzheimer's Disease and other Dementias.