Sex differences in the inferior parietal lobule

Melissa E. Frederikse, Angela Lu, Elizabeth Aylward, Patrick Barta, Godfrey Pearlson

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


The inferior parietal lobule (IPL) - a neocortical region and part of the heteromodal association cortex (HASC) - has been hypothesized to exhibit sexual dimorphism, as do other HASC regions, particularly with regard to asymmetry. Using a reliable method for measuring IPL gray matter volume based upon individual sulcal-gyral landmarks, we measured this region on magnetic resonance imaging scans from a sample of 15 individually matched pairs of normal male and female subjects. Male subjects showed significantly larger left, but not right, IPL volumes when compared to females. Males also showed a leftward (left > right) asymmetry for the IPL, with a less marked opposite asymmetry in females. Such sexual dimorphisms may possibly underlie the subtle cognitive differences observed between the sexes.

Original languageEnglish (US)
Pages (from-to)896-901
Number of pages6
JournalCerebral Cortex
Issue number8
StatePublished - 1999

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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