Sex differences in the effect of puberty on hippocampal morphology

Theodore D. Satterthwaite, Simon Vandekar, Daniel H. Wolf, Kosha Ruparel, David R. Roalf, Chad Jackson, Mark A. Elliott, Warren B. Bilker, Monica E. Calkins, Karthik Prabhakaran, Christos Davatzikos, Hakon Hakonarson, Raquel E. Gur, Ruben C. Gur

Research output: Contribution to journalArticle

Abstract

Objective Puberty is the defining process of adolescence, and is accompanied by divergent trajectories of behavior and cognition for males and females. Here we examine whether sex differences exist in the effect of puberty on the morphology of the hippocampus and amygdala. Method T1-weighted structural neuroimaging was performed in a sample of 524 pre- or postpubertal individuals ages 10 to 22 years. Hippocampal and amygdala volume and shape were quantified using the Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL) FIRST procedure and scaled by intracranial volume. The effects on regional volume of age, sex, puberty, and their interactions were examined using linear regression. Postpubertal sex differences were examined using a vertex analysis. Results Prepubertal males and females had similar hippocampal volumes, whereas postpubertal females had significantly larger bilateral hippocampi, resulting in a significant puberty-by-sex interaction even when controlling for age and age-by-sex. This effect was regionally specific and was not apparent in the amygdala. Vertex analysis revealed that postpubertal differences were most prominent in the lateral aspect of the hippocampus bilaterally, corresponding to the CA1 subfield. Conclusions These results establish that there are regionally specific sex differences in the effect of puberty on the hippocampus. These findings are relevant for the understanding of psychiatric disorders that have both hippocampal dysfunction and prominent gender disparities during adolescence.

Original languageEnglish (US)
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume53
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Fingerprint

Puberty
Sex Characteristics
Hippocampus
Amygdala
Neuroimaging
Cognition
Psychiatry
Linear Models
Software
Magnetic Resonance Imaging
Brain

Keywords

  • development
  • hippocampus
  • magnetic resonance imaging (MRI)
  • puberty

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Satterthwaite, T. D., Vandekar, S., Wolf, D. H., Ruparel, K., Roalf, D. R., Jackson, C., ... Gur, R. C. (2014). Sex differences in the effect of puberty on hippocampal morphology. Journal of the American Academy of Child and Adolescent Psychiatry, 53(3). https://doi.org/10.1016/j.jaac.2013.12.002

Sex differences in the effect of puberty on hippocampal morphology. / Satterthwaite, Theodore D.; Vandekar, Simon; Wolf, Daniel H.; Ruparel, Kosha; Roalf, David R.; Jackson, Chad; Elliott, Mark A.; Bilker, Warren B.; Calkins, Monica E.; Prabhakaran, Karthik; Davatzikos, Christos; Hakonarson, Hakon; Gur, Raquel E.; Gur, Ruben C.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 53, No. 3, 03.2014.

Research output: Contribution to journalArticle

Satterthwaite, TD, Vandekar, S, Wolf, DH, Ruparel, K, Roalf, DR, Jackson, C, Elliott, MA, Bilker, WB, Calkins, ME, Prabhakaran, K, Davatzikos, C, Hakonarson, H, Gur, RE & Gur, RC 2014, 'Sex differences in the effect of puberty on hippocampal morphology', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 53, no. 3. https://doi.org/10.1016/j.jaac.2013.12.002
Satterthwaite, Theodore D. ; Vandekar, Simon ; Wolf, Daniel H. ; Ruparel, Kosha ; Roalf, David R. ; Jackson, Chad ; Elliott, Mark A. ; Bilker, Warren B. ; Calkins, Monica E. ; Prabhakaran, Karthik ; Davatzikos, Christos ; Hakonarson, Hakon ; Gur, Raquel E. ; Gur, Ruben C. / Sex differences in the effect of puberty on hippocampal morphology. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2014 ; Vol. 53, No. 3.
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