Sex differences in the associations of visceral adiposity, homeostatic model assessment of insulin resistance, and body mass index with lipoprotein subclass analysis in obese adolescents

Jacquelyn A. Hatch-Stein, Andrea Kelly, Samuel S. Gidding, Babette S. Zemel, Sheela Magge

Research output: Contribution to journalArticle

Abstract

Background The relationship of lipoprotein particle subclasses to visceral adipose tissue area (VAT-area) in obese children has not been examined previously. Objectives The study aims were to compare the relationships of VAT-area, homeostatic model assessment of insulin resistance (HOMA-IR), and body mass index (BMI) with lipids and lipoprotein subclasses in obese adolescents and to determine whether these relationships vary by sex. Methods This cross-sectional study of obese adolescents (BMI ≥ 95th percentile), aged 12 to 18 years, measured VAT-area by dual-energy X-ray absorptiometry, BMI, fasting lipids, lipoprotein subclasses, and HOMA-IR. Linear regression models evaluated the associations of VAT-area, HOMA-IR, and BMI with lipid cardiometabolic risk factors. Sex-stratified analyses further explored these associations. Results Included were 127 adolescents (age = 14.4 ± 1.5 years; 53.5% female; 88.2% African-American), mean BMI = 34.0 ± 5.1 kg/m2. VAT-area was negatively associated with low-density lipoprotein particle (LDL-P) size (β = −0.28, P = .0001), high-density lipoprotein particle (HDL-P) size (β = −0.33, P < .0001), and large HDL-P concentration (β = −0.29, P < .0001) and positively associated with small LDL-P concentration (β = 0.23, P = .0005) and small HDL-P concentration (β = 0.25, P = .05). When VAT-area, HOMA-IR, and BMI associations were compared, VAT-area had the strongest associations with most of the lipoprotein subclasses. After sex stratification, the associations of VAT-area with HDL cholesterol, LDL-P size, and large LDL-P concentration were significant only for females (all P < .05). Conclusions In a cohort of largely African-American obese adolescents, VAT-area was associated with a more atherogenic lipoprotein subclass profile. When compared with HOMA-IR and BMI, VAT-area had the strongest associations with most lipoprotein subclasses. The relationships between VAT-area and certain lipoprotein subclasses are significantly different in males vs females.

Original languageEnglish (US)
Pages (from-to)757-766
Number of pages10
JournalJournal of Clinical Lipidology
Volume10
Issue number4
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

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Intra-Abdominal Fat
Adiposity
Sex Characteristics
Lipoproteins
Insulin Resistance
Body Mass Index
LDL Lipoproteins
HDL Lipoproteins
Particle Size
Lipids
African Americans
Linear Models
Photon Absorptiometry
HDL Cholesterol
Fasting
Cross-Sectional Studies

Keywords

  • Lipoprotein subclasses
  • Obesity
  • Pediatric
  • Sex differences
  • Visceral fat

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Sex differences in the associations of visceral adiposity, homeostatic model assessment of insulin resistance, and body mass index with lipoprotein subclass analysis in obese adolescents. / Hatch-Stein, Jacquelyn A.; Kelly, Andrea; Gidding, Samuel S.; Zemel, Babette S.; Magge, Sheela.

In: Journal of Clinical Lipidology, Vol. 10, No. 4, 01.07.2016, p. 757-766.

Research output: Contribution to journalArticle

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abstract = "Background The relationship of lipoprotein particle subclasses to visceral adipose tissue area (VAT-area) in obese children has not been examined previously. Objectives The study aims were to compare the relationships of VAT-area, homeostatic model assessment of insulin resistance (HOMA-IR), and body mass index (BMI) with lipids and lipoprotein subclasses in obese adolescents and to determine whether these relationships vary by sex. Methods This cross-sectional study of obese adolescents (BMI ≥ 95th percentile), aged 12 to 18 years, measured VAT-area by dual-energy X-ray absorptiometry, BMI, fasting lipids, lipoprotein subclasses, and HOMA-IR. Linear regression models evaluated the associations of VAT-area, HOMA-IR, and BMI with lipid cardiometabolic risk factors. Sex-stratified analyses further explored these associations. Results Included were 127 adolescents (age = 14.4 ± 1.5 years; 53.5{\%} female; 88.2{\%} African-American), mean BMI = 34.0 ± 5.1 kg/m2. VAT-area was negatively associated with low-density lipoprotein particle (LDL-P) size (β = −0.28, P = .0001), high-density lipoprotein particle (HDL-P) size (β = −0.33, P < .0001), and large HDL-P concentration (β = −0.29, P < .0001) and positively associated with small LDL-P concentration (β = 0.23, P = .0005) and small HDL-P concentration (β = 0.25, P = .05). When VAT-area, HOMA-IR, and BMI associations were compared, VAT-area had the strongest associations with most of the lipoprotein subclasses. After sex stratification, the associations of VAT-area with HDL cholesterol, LDL-P size, and large LDL-P concentration were significant only for females (all P < .05). Conclusions In a cohort of largely African-American obese adolescents, VAT-area was associated with a more atherogenic lipoprotein subclass profile. When compared with HOMA-IR and BMI, VAT-area had the strongest associations with most lipoprotein subclasses. The relationships between VAT-area and certain lipoprotein subclasses are significantly different in males vs females.",
keywords = "Lipoprotein subclasses, Obesity, Pediatric, Sex differences, Visceral fat",
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T1 - Sex differences in the associations of visceral adiposity, homeostatic model assessment of insulin resistance, and body mass index with lipoprotein subclass analysis in obese adolescents

AU - Hatch-Stein, Jacquelyn A.

AU - Kelly, Andrea

AU - Gidding, Samuel S.

AU - Zemel, Babette S.

AU - Magge, Sheela

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background The relationship of lipoprotein particle subclasses to visceral adipose tissue area (VAT-area) in obese children has not been examined previously. Objectives The study aims were to compare the relationships of VAT-area, homeostatic model assessment of insulin resistance (HOMA-IR), and body mass index (BMI) with lipids and lipoprotein subclasses in obese adolescents and to determine whether these relationships vary by sex. Methods This cross-sectional study of obese adolescents (BMI ≥ 95th percentile), aged 12 to 18 years, measured VAT-area by dual-energy X-ray absorptiometry, BMI, fasting lipids, lipoprotein subclasses, and HOMA-IR. Linear regression models evaluated the associations of VAT-area, HOMA-IR, and BMI with lipid cardiometabolic risk factors. Sex-stratified analyses further explored these associations. Results Included were 127 adolescents (age = 14.4 ± 1.5 years; 53.5% female; 88.2% African-American), mean BMI = 34.0 ± 5.1 kg/m2. VAT-area was negatively associated with low-density lipoprotein particle (LDL-P) size (β = −0.28, P = .0001), high-density lipoprotein particle (HDL-P) size (β = −0.33, P < .0001), and large HDL-P concentration (β = −0.29, P < .0001) and positively associated with small LDL-P concentration (β = 0.23, P = .0005) and small HDL-P concentration (β = 0.25, P = .05). When VAT-area, HOMA-IR, and BMI associations were compared, VAT-area had the strongest associations with most of the lipoprotein subclasses. After sex stratification, the associations of VAT-area with HDL cholesterol, LDL-P size, and large LDL-P concentration were significant only for females (all P < .05). Conclusions In a cohort of largely African-American obese adolescents, VAT-area was associated with a more atherogenic lipoprotein subclass profile. When compared with HOMA-IR and BMI, VAT-area had the strongest associations with most lipoprotein subclasses. The relationships between VAT-area and certain lipoprotein subclasses are significantly different in males vs females.

AB - Background The relationship of lipoprotein particle subclasses to visceral adipose tissue area (VAT-area) in obese children has not been examined previously. Objectives The study aims were to compare the relationships of VAT-area, homeostatic model assessment of insulin resistance (HOMA-IR), and body mass index (BMI) with lipids and lipoprotein subclasses in obese adolescents and to determine whether these relationships vary by sex. Methods This cross-sectional study of obese adolescents (BMI ≥ 95th percentile), aged 12 to 18 years, measured VAT-area by dual-energy X-ray absorptiometry, BMI, fasting lipids, lipoprotein subclasses, and HOMA-IR. Linear regression models evaluated the associations of VAT-area, HOMA-IR, and BMI with lipid cardiometabolic risk factors. Sex-stratified analyses further explored these associations. Results Included were 127 adolescents (age = 14.4 ± 1.5 years; 53.5% female; 88.2% African-American), mean BMI = 34.0 ± 5.1 kg/m2. VAT-area was negatively associated with low-density lipoprotein particle (LDL-P) size (β = −0.28, P = .0001), high-density lipoprotein particle (HDL-P) size (β = −0.33, P < .0001), and large HDL-P concentration (β = −0.29, P < .0001) and positively associated with small LDL-P concentration (β = 0.23, P = .0005) and small HDL-P concentration (β = 0.25, P = .05). When VAT-area, HOMA-IR, and BMI associations were compared, VAT-area had the strongest associations with most of the lipoprotein subclasses. After sex stratification, the associations of VAT-area with HDL cholesterol, LDL-P size, and large LDL-P concentration were significant only for females (all P < .05). Conclusions In a cohort of largely African-American obese adolescents, VAT-area was associated with a more atherogenic lipoprotein subclass profile. When compared with HOMA-IR and BMI, VAT-area had the strongest associations with most lipoprotein subclasses. The relationships between VAT-area and certain lipoprotein subclasses are significantly different in males vs females.

KW - Lipoprotein subclasses

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KW - Pediatric

KW - Sex differences

KW - Visceral fat

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