Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline

May A. Beydoun, Adel Boueiz, Marwan S. Abougergi, Melissa H. Kitner-Triolo, Hind A. Beydoun, Susan M. Resnick, Richard O'Brien, Alan B. Zonderman

Research output: Contribution to journalArticle

Abstract

We examined longitudinal associations between the apolipoprotein E ε4 allele (ApoE4+ status) and several cognitive outcomes and tested effect modification by sex. Data on 644 non-Hispanic Caucasian adults, from the Baltimore Longitudinal Study of Aging (BLSA) were used. Dementia onset, cognitive impairment and decline were assessed longitudinally. After 27.5 years median follow-up, 113 participants developed dementia. ApoE4+ predicted dementia significantly (hazard ratio [HR] = 2.89; 95% confidence interval [CI], 1.93-4.33), with nonsignificant sex differences. Taking all time points for predicting cognition, women had significantly stronger positive associations than men between ApoE4+ status and impairment or decline on the California Verbal Learning Test (CVLT; delayed recall and List A total recall) and on Verbal Fluency Test-Categories. This ApoE4 × sex interaction remained significant with Bonferroni correction only for CVLT-delayed recall. Taking time points prior to dementia for cognitive predictions, the positive association between impairment in CVLT-delayed recall and ApoE4+ status remained stronger among women, though only before Bonferroni correction. While ApoE4+ status appears to be a sex neutral risk factor for dementia, its association with verbal memory and learning decline and impairment was stronger among women.

Original languageEnglish (US)
Pages (from-to)720-731.e4
JournalNeurobiology of Aging
Volume33
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Aging
  • Apolipoprotein E genotype
  • Cognitive decline
  • Cognitive impairment
  • Dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Beydoun, M. A., Boueiz, A., Abougergi, M. S., Kitner-Triolo, M. H., Beydoun, H. A., Resnick, S. M., O'Brien, R., & Zonderman, A. B. (2012). Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline. Neurobiology of Aging, 33(4), 720-731.e4. https://doi.org/10.1016/j.neurobiolaging.2010.05.017