Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation

Eleni Sarlani, Edward G. Grace, Mark A. Reynolds, Joel Daniel Greenspan

Research output: Contribution to journalArticle

Abstract

Several studies demonstrate that women are more sensitive to experimental pain than men. In addition, women exhibit greater temporal summation of heat and mechanically evoked pain. Since temporal summation of pain is centrally mediated, its greater expression in women suggests a central nociceptive hyperexcitability relative to men. The purpose of this study was to pursue this theory, by further assessing sex differences in (1) temporal summation of mechanically evoked pain, and (2) aftersensations following repetitive noxious stimulation. Sixteen series of 10 repetitive, mildly noxious, mechanical stimuli were applied to the fingers of 25 women and 25 age-matched men. The subjects rated the pain intensity and unpleasantness caused by the first, fifth and tenth stimulus in the series, as well as their aftersensations 15 s and 1 min following the end of stimulation. Data were analyzed by three-way repeated-measures analysis of variance. Pain and unpleasantness ratings increased with repetition of stimulation (P

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalPain
Volume109
Issue number1-2
DOIs
StatePublished - May 2004
Externally publishedYes

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Sex Characteristics
Pain
Fingers
Analysis of Variance
Hot Temperature

Keywords

  • Aftersensations
  • Gender differences
  • Mechanical nociception
  • Temporal summation
  • Wind-up

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. / Sarlani, Eleni; Grace, Edward G.; Reynolds, Mark A.; Greenspan, Joel Daniel.

In: Pain, Vol. 109, No. 1-2, 05.2004, p. 115-123.

Research output: Contribution to journalArticle

Sarlani, Eleni ; Grace, Edward G. ; Reynolds, Mark A. ; Greenspan, Joel Daniel. / Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. In: Pain. 2004 ; Vol. 109, No. 1-2. pp. 115-123.
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