Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection

Gypsyamber D'Souza; Alicia Wentz; Nicole Kluz; Yuehan Zhang; Elizabeth Sugar; Renee M. Youngfellow; Yingshi Guo; Weihong Xiao; Maura L. Gillison

doi:10.1093/infdis/jiw063

Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection

Gypsyamber D'Souza, Alicia Wentz, Nicole Kluz, Yuehan Zhang, Elizabeth Sugar, Renee M. Youngfellow, Yingshi Guo, Weihong Xiao, Maura L. Gillison

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of oropharyngeal SCC is higher among men than women in the United States. In a cohort study of oral HPV infection among 409 individuals aged 18-25 years, the risk among men but not among women significantly increased as the number of recent (ie, within the prior 3 months) oral sex partners increased (P_interaction =. 05). In contrast, the risk among women but not among men significantly decreased as the lifetime number of vaginal sex partners increased (P_interaction =. 037). Men were also significantly less likely than women to clear oral HPV infection. Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal SCC. Clinical Trials Registration. NCT00994019.

Original language	English (US)
Pages (from-to)	1893-1896
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	213
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiw063
State	Published - Jun 15 2016

Keywords

Epidemiology
Oral HPV
STD clinic
Sex
Young adults

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiw063

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title = "Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection",

abstract = "Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of oropharyngeal SCC is higher among men than women in the United States. In a cohort study of oral HPV infection among 409 individuals aged 18-25 years, the risk among men but not among women significantly increased as the number of recent (ie, within the prior 3 months) oral sex partners increased (Pinteraction =. 05). In contrast, the risk among women but not among men significantly decreased as the lifetime number of vaginal sex partners increased (Pinteraction =. 037). Men were also significantly less likely than women to clear oral HPV infection. Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal SCC. Clinical Trials Registration. NCT00994019.",

keywords = "Epidemiology, Oral HPV, STD clinic, Sex, Young adults",

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AU - D'Souza, Gypsyamber

AU - Wentz, Alicia

AU - Kluz, Nicole

AU - Zhang, Yuehan

AU - Sugar, Elizabeth

AU - Youngfellow, Renee M.

AU - Guo, Yingshi

AU - Xiao, Weihong

AU - Gillison, Maura L.

PY - 2016/6/15

Y1 - 2016/6/15

N2 - Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of oropharyngeal SCC is higher among men than women in the United States. In a cohort study of oral HPV infection among 409 individuals aged 18-25 years, the risk among men but not among women significantly increased as the number of recent (ie, within the prior 3 months) oral sex partners increased (Pinteraction =. 05). In contrast, the risk among women but not among men significantly decreased as the lifetime number of vaginal sex partners increased (Pinteraction =. 037). Men were also significantly less likely than women to clear oral HPV infection. Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal SCC. Clinical Trials Registration. NCT00994019.

AB - Oral human papillomavirus genotype 16 (HPV16) infection causes oropharyngeal squamous cell carcinoma (SCC), and the prevalence of oropharyngeal SCC is higher among men than women in the United States. In a cohort study of oral HPV infection among 409 individuals aged 18-25 years, the risk among men but not among women significantly increased as the number of recent (ie, within the prior 3 months) oral sex partners increased (Pinteraction =. 05). In contrast, the risk among women but not among men significantly decreased as the lifetime number of vaginal sex partners increased (Pinteraction =. 037). Men were also significantly less likely than women to clear oral HPV infection. Our data contribute to understanding sex differences in risk for HPV-positive oropharyngeal SCC. Clinical Trials Registration. NCT00994019.

KW - Epidemiology

KW - Oral HPV

KW - STD clinic

KW - Sex

KW - Young adults

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ER -

Sex Differences in Risk Factors and Natural History of Oral Human Papillomavirus Infection

Abstract

Keywords

ASJC Scopus subject areas

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