Sex differences in pediatric traumatic brain injury

Sheryl E. Arambula, Erin L. Reinl, Nagat El Demerdash, Margaret M. McCarthy, Courtney L. Robertson

Research output: Contribution to journalReview articlepeer-review

Abstract

The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.

Original languageEnglish (US)
Pages (from-to)168-179
Number of pages12
JournalExperimental Neurology
Volume317
DOIs
StatePublished - Jul 2019

Keywords

  • Cerebral metabolism
  • Excitotoxicity
  • Gender
  • Mitochondria
  • Neuroinflammation
  • Sex

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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