Sex Differences in Neurocognitive Function in Adults with HIV

Patterns, Predictors, and Mechanisms

Leah Rubin, Gretchen N. Neigh, Erin E. Sundermann, Yanxun Xu, Eileen Scully, Pauline M. Maki

Research output: Contribution to journalReview article

Abstract

PURPOSE OF REVIEW: Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI. RECENT FINDINGS: We conducted a systematic review of recent studies of NCI in WLWH versus MLWH. A power analysis showed that few HIV studies have sufficient power to address male/female differences in NCI but studies with adequate power find evidence of greater NCI in WLWH, particularly in the domains of memory, speed of information processing, and motor function. Sex is an important determinant of NCI in HIV, and may relate to male/female differences in cognitive reserve, comorbidities (mental health and substance use disorders), and biological factors (e.g., inflammation, hormonal, genetic).

Original languageEnglish (US)
Number of pages1
JournalCurrent psychiatry reports
Volume21
Issue number10
DOIs
StatePublished - Sep 14 2019

Fingerprint

Sex Characteristics
HIV
Cognitive Reserve
Biological Factors
Automatic Data Processing
Cognition
Substance-Related Disorders
Comorbidity
Mental Health
Inflammation
Power (Psychology)

Keywords

  • Cognition
  • HIV
  • Neurocognition
  • Sex differences

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sex Differences in Neurocognitive Function in Adults with HIV : Patterns, Predictors, and Mechanisms. / Rubin, Leah; Neigh, Gretchen N.; Sundermann, Erin E.; Xu, Yanxun; Scully, Eileen; Maki, Pauline M.

In: Current psychiatry reports, Vol. 21, No. 10, 14.09.2019.

Research output: Contribution to journalReview article

Rubin, Leah ; Neigh, Gretchen N. ; Sundermann, Erin E. ; Xu, Yanxun ; Scully, Eileen ; Maki, Pauline M. / Sex Differences in Neurocognitive Function in Adults with HIV : Patterns, Predictors, and Mechanisms. In: Current psychiatry reports. 2019 ; Vol. 21, No. 10.
@article{8abd8809e46c4b469e6122c75b73e1a3,
title = "Sex Differences in Neurocognitive Function in Adults with HIV: Patterns, Predictors, and Mechanisms",
abstract = "PURPOSE OF REVIEW: Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI. RECENT FINDINGS: We conducted a systematic review of recent studies of NCI in WLWH versus MLWH. A power analysis showed that few HIV studies have sufficient power to address male/female differences in NCI but studies with adequate power find evidence of greater NCI in WLWH, particularly in the domains of memory, speed of information processing, and motor function. Sex is an important determinant of NCI in HIV, and may relate to male/female differences in cognitive reserve, comorbidities (mental health and substance use disorders), and biological factors (e.g., inflammation, hormonal, genetic).",
keywords = "Cognition, HIV, Neurocognition, Sex differences",
author = "Leah Rubin and Neigh, {Gretchen N.} and Sundermann, {Erin E.} and Yanxun Xu and Eileen Scully and Maki, {Pauline M.}",
year = "2019",
month = "9",
day = "14",
doi = "10.1007/s11920-019-1089-x",
language = "English (US)",
volume = "21",
journal = "Current Psychiatry Reports",
issn = "1523-3812",
publisher = "Current Science, Inc.",
number = "10",

}

TY - JOUR

T1 - Sex Differences in Neurocognitive Function in Adults with HIV

T2 - Patterns, Predictors, and Mechanisms

AU - Rubin, Leah

AU - Neigh, Gretchen N.

AU - Sundermann, Erin E.

AU - Xu, Yanxun

AU - Scully, Eileen

AU - Maki, Pauline M.

PY - 2019/9/14

Y1 - 2019/9/14

N2 - PURPOSE OF REVIEW: Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI. RECENT FINDINGS: We conducted a systematic review of recent studies of NCI in WLWH versus MLWH. A power analysis showed that few HIV studies have sufficient power to address male/female differences in NCI but studies with adequate power find evidence of greater NCI in WLWH, particularly in the domains of memory, speed of information processing, and motor function. Sex is an important determinant of NCI in HIV, and may relate to male/female differences in cognitive reserve, comorbidities (mental health and substance use disorders), and biological factors (e.g., inflammation, hormonal, genetic).

AB - PURPOSE OF REVIEW: Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI. RECENT FINDINGS: We conducted a systematic review of recent studies of NCI in WLWH versus MLWH. A power analysis showed that few HIV studies have sufficient power to address male/female differences in NCI but studies with adequate power find evidence of greater NCI in WLWH, particularly in the domains of memory, speed of information processing, and motor function. Sex is an important determinant of NCI in HIV, and may relate to male/female differences in cognitive reserve, comorbidities (mental health and substance use disorders), and biological factors (e.g., inflammation, hormonal, genetic).

KW - Cognition

KW - HIV

KW - Neurocognition

KW - Sex differences

UR - http://www.scopus.com/inward/record.url?scp=85072180514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072180514&partnerID=8YFLogxK

U2 - 10.1007/s11920-019-1089-x

DO - 10.1007/s11920-019-1089-x

M3 - Review article

VL - 21

JO - Current Psychiatry Reports

JF - Current Psychiatry Reports

SN - 1523-3812

IS - 10

ER -