Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters

Timothy R. Sterling, Cynthia M. Lyles, David Vlahov, Jacquie Astemborski, Joseph B. Margolick, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

Cross-sectional studies have demonstrated lower plasma human immunodeficiency virus type 1 (HIV-1) RNA virus levels (VLs) in women than in men, but it is unknown whether this sex difference is present at the time of seroconversion and throughout the course of infection. A nested case-control study was performed among HIV-1 seroconverters within a cohort of injection drug users. Plasma VL was determined longitudinally among both rapid progressors to AIDS (24 patients) and nonprogressors (47 controls). The initial median VL among female patients (n = 10) was 14,918 copies/mL, compared with 148,354 copies/mL among male patients (n = 14; P = .001); median plasma VL also tended to be lower among female (n = 10) than among male controls (n = 37; 11,917 vs. 61,311 copies/mL; P = .08). VL increased more rapidly over time in women than in men and subsequently converged in patients and controls, respectively. Understanding the mechanisms responsible for the sex difference in VL may provide insight into HIV-1 pathogenesis.

Original languageEnglish (US)
Pages (from-to)666-672
Number of pages7
JournalJournal of Infectious Diseases
Volume180
Issue number3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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