Sex Differences in Infectious and Autoimmune Diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter begins with a discussion of sex differences in death rates and disease susceptibility. It then discusses sex differences in infectious diseases, covering susceptibility to viruses, bacteria, and parasites. This is followed by discussion of sex differences in autoimmune diseases, immunological differences between the sexes, sex steroid-immune interactions, and the influence of genetic factors on sex differences in disease susceptibility. The sexes differ in their responses to infectious and autoimmune diseases. The intensity and prevalence of infectious diseases typically are higher in males than females; conversely, the prevalence and severity of autoimmune diseases are greater in females than males. Endocrine-immune interactions play a fundamental role mediating responses to diseases. Because sex steroid concentrations differ dramatically between the sexes, to date, most studies have focused on characterizing the role of sex steroids as mediators of sex differences in immune function.

Original languageEnglish (US)
Title of host publicationSex Differences in the Brain: From Genes to Behavior
PublisherOxford University Press
ISBN (Print)9780199865048, 9780195311587
DOIs
StatePublished - Dec 4 2007

Fingerprint

Sex Characteristics
Autoimmune Diseases
Communicable Diseases
Disease Susceptibility
Steroids
Parasites
Viruses
Bacteria
Mortality

Keywords

  • Autoimmune diseases
  • Disease susceptibility
  • Immune function
  • Infectious disease
  • Sex differences

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Klein, S. L. (2007). Sex Differences in Infectious and Autoimmune Diseases. In Sex Differences in the Brain: From Genes to Behavior Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195311587.003.0017

Sex Differences in Infectious and Autoimmune Diseases. / Klein, Sabra L.

Sex Differences in the Brain: From Genes to Behavior. Oxford University Press, 2007.

Research output: Chapter in Book/Report/Conference proceedingChapter

Klein, SL 2007, Sex Differences in Infectious and Autoimmune Diseases. in Sex Differences in the Brain: From Genes to Behavior. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195311587.003.0017
Klein SL. Sex Differences in Infectious and Autoimmune Diseases. In Sex Differences in the Brain: From Genes to Behavior. Oxford University Press. 2007 https://doi.org/10.1093/acprof:oso/9780195311587.003.0017
Klein, Sabra L. / Sex Differences in Infectious and Autoimmune Diseases. Sex Differences in the Brain: From Genes to Behavior. Oxford University Press, 2007.
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