Sex differences in immune responses and viral shedding following Seoul virus infection in Norway rats

S. L. Klein, B. H. Bird, G. E. Glass

Research output: Contribution to journalArticlepeer-review

Abstract

In the field, male rodents are more frequently infected with hantaviruses than females. This study examined whether patterns of immune responses against hantavirus differed between the sexes. Male and female Long Evans rats (Rattus norvegicus) were inoculated with Seoul virus, and antibody and cytokine responses, as well as virus shedding were assessed. Males were more likely to shed virus in saliva, to shed virus through multiple routes (saliva, urine, and feces), and to have viral RNA in the spleen than females. Anti-Seoul virus IgG responses were higher in males than females. In both sexes, splenic IFNγ and IL-4 production increased following infection. After infection, males had higher Th1 immune responses (i.e., IgG2a, IFNγ, and IL-2) than females; in contrast, Th2 immune responses (i.e., IgG1, IL-4, and IL-10) were similar between the sexes. These data suggest that immune responses to Seoul virus differ between the sexes.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume65
Issue number1
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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