Sex differences in endogenous pain modulation by distracting and painful conditioning stimulation

Raimi L. Quiton, Joel Daniel Greenspan

Research output: Contribution to journalArticle

Abstract

Sex differences in endogenous pain modulation were tested in healthy volunteers (32 men, 30 women). Painful contact heat stimuli were delivered to the right leg alone, and then in combination with various electrical conditioning stimuli delivered to the left forearm. Four conditioning protocols were applied to each subject in separate sessions: mild, non-painful (control); distracting; stressful-yet-non-painful; strongly painful. Thermal stimuli were rated on visual analog scales for pain intensity (INT) and unpleasantness (UNP). Distracting and painful conditioning stimuli significantly reduced heat pain INT and UNP ratings for both sexes, with significantly larger distraction effects on INT ratings for men than women (p = 0.004). No sex differences in pain-evoked hypoalgesia were detected (p > 0.05). The stress protocol did not consistently reduce heat pain ratings, possibly because the protocol was not sufficiently stressful to activate endogenous modulatory systems. Regression analysis revealed that the magnitude of pain-evoked hypoalgesia was predicted by the perceived distraction (p = 0.003) and stress (p = 0.04) produced by the painful conditioning stimulation, providing evidence that distraction and stress contribute to pain-evoked hypoalgesia. However, the contribution of stress to pain-evoked hypoalgesia differed by sex (p = 0.02), with greater perceived stress associated with greater hypoalgesia in men and the opposite trend in women, suggesting sex differences in the mechanisms underlying pain-evoked hypoalgesia. This study provides indirect evidence that multiple neural mechanisms are involved in endogenous pain modulation and suggests that sex-specific aspects of these systems may contribute to greater pain sensitivity and higher prevalence of many chronic pain conditions among women.

Original languageEnglish (US)
JournalPain
Volume132
Issue numberSUPPL. 1
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Sex Characteristics
Pain
Hot Temperature
Conditioning (Psychology)
Pain Measurement
Forearm
Chronic Pain
Leg
Healthy Volunteers
Regression Analysis

Keywords

  • Distraction
  • DNIC
  • Endogenous analgesia
  • Pain
  • Sex
  • Stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Sex differences in endogenous pain modulation by distracting and painful conditioning stimulation. / Quiton, Raimi L.; Greenspan, Joel Daniel.

In: Pain, Vol. 132, No. SUPPL. 1, 11.2007.

Research output: Contribution to journalArticle

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