Sex dependent behavioral response to frontal cortical suction lesions in the rat

John R. Lipsey, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

Abstract

Previous reports indicate that male rats given right (but not left) frontal cortical suction lesions develop hyperactivity accompanied by cortical norepinephrine depletions (9, 10). In this study, female rats given such lesions to either hemisphere developed bilateral cortical norepinephrine depletions but no hyperactivity. Right lesion male rats developed both catecholamine depletions and hyperactivity. Thus, the lateralized hyperactivity response to these cortical lesions is sex-dependent and may involve sex differences in subcortical neural pathways.

Original languageEnglish (US)
Pages (from-to)2185-2192
Number of pages8
JournalLife Sciences
Volume38
Issue number24
DOIs
StatePublished - Jun 16 1986

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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