Sex chromatin pattern in hydatidiform mole

Michael S. Baggish, J. Donald Woodruff, S. H. Tow, Howard W. Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Ninety cases of hydatidiform mole were investigated for the presence of the sex chromatin body. Well-defined heterochromatic bodies were found in every section. In 79 cases (88 per cent) 15 or more chromatin-positive cells were identified per 100 cells counted. Previous investigations have shown that these findings cannot be explained on the basis of polyploidy. It is suggested that two cell lines develop in hydatidiform mole, one line representing the union of the sperm and ovum; the second by endoreduplication of the second polocyte. This could account for the coexistence of a mole and fetus, for the mole alone, and for "molar degeneration of the placenta." Again, in all these instances the sex of the mole is predominantly female.

Original languageEnglish (US)
Pages (from-to)362-370
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Volume102
Issue number3
DOIs
StatePublished - Oct 1 1968

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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