Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6

Joonhee Cho, Lina Kim, Zhaoxia Li, Noel R. Rose, Monica Vladut Talor, Dolores B Njoku

Research output: Contribution to journalArticle

Abstract

Background and Aims: Immune-mediated, drug-induced liver injury (DILI) triggered by drug haptens is more prevalent in women than in men. However, mechanisms responsible for this sex bias are not clear. Immune regulation by CD4+CD25+FoxP3+ regulatory T-cells (Tregs) and 17β-estradiol is crucial in the pathogenesis of sex bias in cancer and autoimmunity. Therefore, we investigated their role in a mouse model of immune-mediated DILI. Methods: To model DILI, we immunized BALB/c, BALB/cBy, IL-6-deficient, and castrated BALB/c mice with trifluoroacetyl chloride-haptenated liver proteins. We then measured degree of hepatitis, cytokines, antibodies, and Treg and splenocyte function. Results: BALB/c females developed more severe hepatitis (p

Original languageEnglish (US)
Article numbere61186
JournalPLoS One
Volume8
Issue number4
DOIs
StatePublished - Apr 5 2013

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Chemical and Drug Induced Liver Injury
Sexism
interleukin-6
Liver
estrogens
Interleukin-6
Estrogens
drugs
liver
gender
mice
hepatitis
Hepatitis Antibodies
Pharmaceutical Preparations
Safe Sex
Haptens
Regulatory T-Lymphocytes
Autoimmunity
liver protein
haptens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice : Suggested Roles for Tregs, Estrogen, and IL-6. / Cho, Joonhee; Kim, Lina; Li, Zhaoxia; Rose, Noel R.; Talor, Monica Vladut; Njoku, Dolores B.

In: PLoS One, Vol. 8, No. 4, e61186, 05.04.2013.

Research output: Contribution to journalArticle

Cho, Joonhee ; Kim, Lina ; Li, Zhaoxia ; Rose, Noel R. ; Talor, Monica Vladut ; Njoku, Dolores B. / Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice : Suggested Roles for Tregs, Estrogen, and IL-6. In: PLoS One. 2013 ; Vol. 8, No. 4.
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