The relationship between sex and heroin has been the subject of much research and more lucubration. The authors postulate on the basis of correlative animal work that acute heroin administration has a central effect on the release of hypothalamic luteinizing hormone releasing factor (LRF). The regulation of LH via LRF has been localized to ventral and medial areas of the hypothalamus, areas possessing many opiate receptor binding sites and a high concentration of endogenous opiate peptides. In an effort to synthesize clinical and physiological knowledge, the authors postulate that the intensive pleasurable 'rush' which follows intravenous injection of heroin involves massive release of catecholamines at both central and peripheral sites. The authors are unable to document this suspicion. Fortunately, they have left some work for the rest of us.
ASJC Scopus subject areas
- Psychiatry and Mental health