TY - JOUR
T1 - Sex-and gender-based pharmacological response to drugss
AU - Mauvais-Jarvis, Franck
AU - Berthold, Heiner K.
AU - Campesi, Ilaria
AU - Carrero, Juan Jesus
AU - Dakal, Santosh
AU - Franconi, Flavia
AU - Gouni-Berthold, Ioanna
AU - Heiman, Mark L.
AU - Kautzky-Willer, Alexandra
AU - Klein, Sabra L.
AU - Murphy, Anne
AU - Regitz-Zagrosek, Vera
AU - Reue, Karen
AU - Rubin, Joshua B.
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) awards from National Institute of Diabetes and Digestive and Kidney Diseases [Grants DK074970 and DK107444] (to F.M.-J.), [Grant DK121594-01] (to M.L.H.), and [Grant DK120342] (to K.R.); National Institute of General Medical Sciences [Grant GM122130] (to M.I.H.); and National Institute on Drug Abuse [Grant DA041529] (to A.M.). US Department of Veterans Affairs Merit Review Award was given to F.M.-J. [Grant BX003725]. J.-J.C. was supported by Swedish Research Council [Grant 2019-01059]. V.R.-Z. was supported by the Anna Fischer Dueckelman guest professorship at the University of Zurich.
Publisher Copyright:
© 2021 by The American Society for Pharmacology and Experimental Therapeutics.
PY - 2021/4
Y1 - 2021/4
N2 - ——In humans, the combination of all sexspecific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women. Significance Statement——This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.
AB - ——In humans, the combination of all sexspecific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women. Significance Statement——This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.
UR - http://www.scopus.com/inward/record.url?scp=85102331704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102331704&partnerID=8YFLogxK
U2 - 10.1124/pharmrev.120.000206
DO - 10.1124/pharmrev.120.000206
M3 - Article
C2 - 33653873
AN - SCOPUS:85102331704
SN - 0031-6997
VL - 73
SP - 730
EP - 762
JO - Pharmacological reviews
JF - Pharmacological reviews
IS - 2
ER -