Sex- and age-related differences in ceramide dihexosides of primary human brain tumors

Allan J. Yates; Teresa K. Franklin; Berndt W. Scheithauer; Peter C. Burger; Dennis K. Pearl

doi:10.1007/s11745-999-330-7

Sex- and age-related differences in ceramide dihexosides of primary human brain tumors

Allan J. Yates, Teresa K. Franklin, Berndt W. Scheithauer, Peter C. Burger, Dennis K. Pearl

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Lipids
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/s11745-999-330-7
State	Published - 1999

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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title = "Sex- and age-related differences in ceramide dihexosides of primary human brain tumors",

abstract = "Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.",

author = "Yates, {Allan J.} and Franklin, {Teresa K.} and Scheithauer, {Berndt W.} and Burger, {Peter C.} and Pearl, {Dennis K.}",

note = "Funding Information: This work was supported by grants from The National Cancer Institute UO1-CA50910, UO1-CA50905, and UO1-CA64928.",

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AU - Yates, Allan J.

AU - Franklin, Teresa K.

AU - Scheithauer, Berndt W.

AU - Burger, Peter C.

AU - Pearl, Dennis K.

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N2 - Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.

AB - Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.

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Sex- and age-related differences in ceramide dihexosides of primary human brain tumors

Abstract

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