Sex- and age-related differences in ceramide dihexosides of primary human brain tumors

Allan J. Yates, Teresa K. Franklin, Berndt W. Scheithauer, Peter C. Burger, Dennis K. Pearl

Research output: Contribution to journalArticle

Abstract

Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalLipids
Volume34
Issue number1
StatePublished - 1999

Fingerprint

ceramides
glycolipids
Glycolipids
Brain Neoplasms
Tumors
Brain
brain
neoplasms
gender
Glioma
menopause
sex hormones
Gonadal Steroid Hormones
puberty
Puberty
Menopause
Sex Characteristics
pathogenesis
kidneys
Kidney

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Yates, A. J., Franklin, T. K., Scheithauer, B. W., Burger, P. C., & Pearl, D. K. (1999). Sex- and age-related differences in ceramide dihexosides of primary human brain tumors. Lipids, 34(1), 1-4.

Sex- and age-related differences in ceramide dihexosides of primary human brain tumors. / Yates, Allan J.; Franklin, Teresa K.; Scheithauer, Berndt W.; Burger, Peter C.; Pearl, Dennis K.

In: Lipids, Vol. 34, No. 1, 1999, p. 1-4.

Research output: Contribution to journalArticle

Yates, AJ, Franklin, TK, Scheithauer, BW, Burger, PC & Pearl, DK 1999, 'Sex- and age-related differences in ceramide dihexosides of primary human brain tumors', Lipids, vol. 34, no. 1, pp. 1-4.
Yates AJ, Franklin TK, Scheithauer BW, Burger PC, Pearl DK. Sex- and age-related differences in ceramide dihexosides of primary human brain tumors. Lipids. 1999;34(1):1-4.
Yates, Allan J. ; Franklin, Teresa K. ; Scheithauer, Berndt W. ; Burger, Peter C. ; Pearl, Dennis K. / Sex- and age-related differences in ceramide dihexosides of primary human brain tumors. In: Lipids. 1999 ; Vol. 34, No. 1. pp. 1-4.
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