Sex and Age Effects on the Inheritance of Alcohol Problems: A Twin Study

Matt McGue, Roy W. Pickens, Dace S. Svikis

Research output: Contribution to journalArticle

Abstract

Male monozygotic cotwins of probands with Alcohol Abuse-Dependence (n = 85) were more likely than male same-sex dizygotic cotwins (n = 96) to report alcohol, drug, and conduct disorder problems. For women, rates of problem behavior did not differ between monozygotic (n = 44) and same-sex dizygotic (n = 43) cotwins. Opposite-sex dizygotic twin data (n = 88) revealed significant cross-sex transmission; alcohol problems were greatest among male cotwins of female probands. For men, proportion of liability variance associated with additive genetic factors was significantly greater when proband had an early (h2 = .73 ± .18) rather than late (h2 = .30 ± .26) age of onset. For women, heritability did not vary as a function of proband's age of onset, and the pooled estimate suggested little genetic influence (h2 = .00, SE not computable). Findings suggest that genetic influences may be substantial only in the etiology of early-onset male alcoholism.

Original languageEnglish (US)
Pages (from-to)3-17
Number of pages15
JournalJournal of Abnormal Psychology
Volume101
Issue number1
StatePublished - Feb 1992

Fingerprint

Twin Studies
Alcohols
Alcoholism
Age of Onset
Dizygotic Twins
Conduct Disorder
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychology(all)
  • Experimental and Cognitive Psychology

Cite this

McGue, M., Pickens, R. W., & Svikis, D. S. (1992). Sex and Age Effects on the Inheritance of Alcohol Problems: A Twin Study. Journal of Abnormal Psychology, 101(1), 3-17.

Sex and Age Effects on the Inheritance of Alcohol Problems : A Twin Study. / McGue, Matt; Pickens, Roy W.; Svikis, Dace S.

In: Journal of Abnormal Psychology, Vol. 101, No. 1, 02.1992, p. 3-17.

Research output: Contribution to journalArticle

McGue, M, Pickens, RW & Svikis, DS 1992, 'Sex and Age Effects on the Inheritance of Alcohol Problems: A Twin Study', Journal of Abnormal Psychology, vol. 101, no. 1, pp. 3-17.
McGue, Matt ; Pickens, Roy W. ; Svikis, Dace S. / Sex and Age Effects on the Inheritance of Alcohol Problems : A Twin Study. In: Journal of Abnormal Psychology. 1992 ; Vol. 101, No. 1. pp. 3-17.
@article{e849fa0dc337427396cd050152b8a0f2,
title = "Sex and Age Effects on the Inheritance of Alcohol Problems: A Twin Study",
abstract = "Male monozygotic cotwins of probands with Alcohol Abuse-Dependence (n = 85) were more likely than male same-sex dizygotic cotwins (n = 96) to report alcohol, drug, and conduct disorder problems. For women, rates of problem behavior did not differ between monozygotic (n = 44) and same-sex dizygotic (n = 43) cotwins. Opposite-sex dizygotic twin data (n = 88) revealed significant cross-sex transmission; alcohol problems were greatest among male cotwins of female probands. For men, proportion of liability variance associated with additive genetic factors was significantly greater when proband had an early (h2 = .73 ± .18) rather than late (h2 = .30 ± .26) age of onset. For women, heritability did not vary as a function of proband's age of onset, and the pooled estimate suggested little genetic influence (h2 = .00, SE not computable). Findings suggest that genetic influences may be substantial only in the etiology of early-onset male alcoholism.",
author = "Matt McGue and Pickens, {Roy W.} and Svikis, {Dace S.}",
year = "1992",
month = "2",
language = "English (US)",
volume = "101",
pages = "3--17",
journal = "Journal of Abnormal Psychology",
issn = "0021-843X",
publisher = "American Psychological Association Inc.",
number = "1",

}

TY - JOUR

T1 - Sex and Age Effects on the Inheritance of Alcohol Problems

T2 - A Twin Study

AU - McGue, Matt

AU - Pickens, Roy W.

AU - Svikis, Dace S.

PY - 1992/2

Y1 - 1992/2

N2 - Male monozygotic cotwins of probands with Alcohol Abuse-Dependence (n = 85) were more likely than male same-sex dizygotic cotwins (n = 96) to report alcohol, drug, and conduct disorder problems. For women, rates of problem behavior did not differ between monozygotic (n = 44) and same-sex dizygotic (n = 43) cotwins. Opposite-sex dizygotic twin data (n = 88) revealed significant cross-sex transmission; alcohol problems were greatest among male cotwins of female probands. For men, proportion of liability variance associated with additive genetic factors was significantly greater when proband had an early (h2 = .73 ± .18) rather than late (h2 = .30 ± .26) age of onset. For women, heritability did not vary as a function of proband's age of onset, and the pooled estimate suggested little genetic influence (h2 = .00, SE not computable). Findings suggest that genetic influences may be substantial only in the etiology of early-onset male alcoholism.

AB - Male monozygotic cotwins of probands with Alcohol Abuse-Dependence (n = 85) were more likely than male same-sex dizygotic cotwins (n = 96) to report alcohol, drug, and conduct disorder problems. For women, rates of problem behavior did not differ between monozygotic (n = 44) and same-sex dizygotic (n = 43) cotwins. Opposite-sex dizygotic twin data (n = 88) revealed significant cross-sex transmission; alcohol problems were greatest among male cotwins of female probands. For men, proportion of liability variance associated with additive genetic factors was significantly greater when proband had an early (h2 = .73 ± .18) rather than late (h2 = .30 ± .26) age of onset. For women, heritability did not vary as a function of proband's age of onset, and the pooled estimate suggested little genetic influence (h2 = .00, SE not computable). Findings suggest that genetic influences may be substantial only in the etiology of early-onset male alcoholism.

UR - http://www.scopus.com/inward/record.url?scp=0026571276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026571276&partnerID=8YFLogxK

M3 - Article

C2 - 1537970

AN - SCOPUS:0026571276

VL - 101

SP - 3

EP - 17

JO - Journal of Abnormal Psychology

JF - Journal of Abnormal Psychology

SN - 0021-843X

IS - 1

ER -