Severity of episcleritis and systemic disease association

Esen K Akpek, Harvey S. Uy, William Christen, Canan Gurdal, C. Stephen Foster

Research output: Contribution to journalArticle

Abstract

Objective: To analyze patient characteristics and correlate between the site and severity of the inflammation and ocular and/or systemic disease association in a cohort of patients with episcleritis. Design: Retrospective case series. Methods: Medical records of 100 patients with episcleritis were reviewed. Data were analyzed using a customized database software. Results: The age range at presentation was 18 to 76 years (mean, 43; median, 44). Sixty-nine percent of the patients were female. Thirty-two (32%) patients had bilateral involvement. The episcleritis was nodular in 23 eyes (16%). Half of the patients had a concurrent eye disease. Associated systemic disease was found in 36 patients (36%). In two patients, episcleritis preceded a systemic vasculitic disease (Wegener granulomatosis and Cogan syndrome). Ocular complications included uveitis (11.4%), corneal involvement (15%), and glaucoma (7.8%). No significant correlation of the site and severity of inflammation to the presence of associated systemic or ocular diseases was found. The mean follow-up was 16.5 months. Twenty-eight patients experienced recurrence of episcleritis during the follow-up. Half of the patients required treatment with oral nonsteroidal anti-inflammatory drugs. Conclusions: Episcleritis is usually a benign, self-limited disease, but it should not be trivialized since it may be associated with systemic disease and ocular complications. A careful review of systems should be performed in all patients presenting with episcleritis, and this should be repeated at least annually during the follow-up. A thorough eye examination is obviously essential to detect and treat ocular complications.

Original languageEnglish (US)
Pages (from-to)729-731
Number of pages3
JournalOphthalmology
Volume106
Issue number4
StatePublished - Apr 1 1999
Externally publishedYes

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Scleritis
Eye Diseases
Cogan Syndrome
Inflammation
Granulomatosis with Polyangiitis
Uveitis
Glaucoma
Medical Records
Anti-Inflammatory Agents
Software

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Akpek, E. K., Uy, H. S., Christen, W., Gurdal, C., & Foster, C. S. (1999). Severity of episcleritis and systemic disease association. Ophthalmology, 106(4), 729-731.

Severity of episcleritis and systemic disease association. / Akpek, Esen K; Uy, Harvey S.; Christen, William; Gurdal, Canan; Foster, C. Stephen.

In: Ophthalmology, Vol. 106, No. 4, 01.04.1999, p. 729-731.

Research output: Contribution to journalArticle

Akpek, EK, Uy, HS, Christen, W, Gurdal, C & Foster, CS 1999, 'Severity of episcleritis and systemic disease association', Ophthalmology, vol. 106, no. 4, pp. 729-731.
Akpek EK, Uy HS, Christen W, Gurdal C, Foster CS. Severity of episcleritis and systemic disease association. Ophthalmology. 1999 Apr 1;106(4):729-731.
Akpek, Esen K ; Uy, Harvey S. ; Christen, William ; Gurdal, Canan ; Foster, C. Stephen. / Severity of episcleritis and systemic disease association. In: Ophthalmology. 1999 ; Vol. 106, No. 4. pp. 729-731.
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