Severe Treatment-Related Lymphopenia in Patients with Newly Diagnosed Rectal Cancer

Jian L. Campian, Xiaobu Ye, Guneet Sarai, Joseph Herman, Stuart A. Grossman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although treatment-related lymphopenia (TRL) is common in many cancers no data exists in rectal cancer. Methods: Serial lymphocyte counts were analyzed retrospectively in patients with newly diagnosed rectal cancer, serial blood counts, and complete records at Johns Hopkins Hospital. Results: Fifty-seven patients with normal pretreatment lymphocyte counts were studied. Two months after beginning chemoradiation, 35% of these patients developed grade III-IV lymphopenia [median lymphocyte counts fell from 1590 to 490 cell/mm3 (p < 0.001)] which persisted throughout one year of observation. Conclusion: Severe and prolonged TRL is common in rectal cancer. Further studies are required to determine TRL’s relationship to survival.

Original languageEnglish (US)
JournalCancer Investigation
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Lymphopenia
  • Radiation
  • Rectal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Severe Treatment-Related Lymphopenia in Patients with Newly Diagnosed Rectal Cancer'. Together they form a unique fingerprint.

Cite this