Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome

K. H. Yeh, H. C. Hsieh, J. L. Tang, M. T. Lin, C. H. Yang, Y. C. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.

Original languageEnglish (US)
Pages (from-to)319-321
Number of pages3
JournalBone marrow transplantation
Volume14
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome'. Together they form a unique fingerprint.

Cite this