Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome

K. H. Yeh; H. C. Hsieh; J. L. Tang; M. T. Lin; C. H. Yang; Y. C. Chen

Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome

K. H. Yeh, H. C. Hsieh, J. L. Tang, M. T. Lin, C. H. Yang, Y. C. Chen

Research output: Contribution to journal › Article › peer-review

Abstract

A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.

Original language	English (US)
Pages (from-to)	319-321
Number of pages	3
Journal	Bone marrow transplantation
Volume	14
Issue number	2
State	Published - Jan 1 1994
Externally published	Yes

ASJC Scopus subject areas

Hematology
Transplantation

Cite this

@article{1c8ff69ec6044a79ac89a51c23100b66,

title = "Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome",

abstract = "A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.",

author = "Yeh, {K. H.} and Hsieh, {H. C.} and Tang, {J. L.} and Lin, {M. T.} and Yang, {C. H.} and Chen, {Y. C.}",

year = "1994",

month = jan,

day = "1",

language = "English (US)",

volume = "14",

pages = "319--321",

journal = "Bone marrow transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome

AU - Yeh, K. H.

AU - Hsieh, H. C.

AU - Tang, J. L.

AU - Lin, M. T.

AU - Yang, C. H.

AU - Chen, Y. C.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.

AB - A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.

UR - http://www.scopus.com/inward/record.url?scp=0027954040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027954040&partnerID=8YFLogxK

M3 - Article

C2 - 7994249

AN - SCOPUS:0027954040

SN - 0268-3369

VL - 14

SP - 319

EP - 321

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 2

ER -

Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this