Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")

George Ricaurte, Jie Yuan, George Hatzidimitriou, Branden J. Cord, Una D McCann

Research output: Contribution to journalArticle

Abstract

The prevailing view is that the popular recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.

Original languageEnglish (US)
Pages (from-to)2260-2263
Number of pages4
JournalScience
Volume297
Issue number5590
DOIs
StatePublished - Sep 27 2002

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Primates
Dopamine
Serotonin
Neurotoxins
Brain
Street Drugs
Young Adult

ASJC Scopus subject areas

  • General

Cite this

Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). / Ricaurte, George; Yuan, Jie; Hatzidimitriou, George; Cord, Branden J.; McCann, Una D.

In: Science, Vol. 297, No. 5590, 27.09.2002, p. 2260-2263.

Research output: Contribution to journalArticle

Ricaurte, George ; Yuan, Jie ; Hatzidimitriou, George ; Cord, Branden J. ; McCann, Una D. / Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). In: Science. 2002 ; Vol. 297, No. 5590. pp. 2260-2263.
@article{41507aec66c04d8d9d4526781b3060dd,
title = "Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ({"}ecstasy{"})",
abstract = "The prevailing view is that the popular recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, or {"}ecstasy{"}) is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.",
author = "George Ricaurte and Jie Yuan and George Hatzidimitriou and Cord, {Branden J.} and McCann, {Una D}",
year = "2002",
month = "9",
day = "27",
doi = "10.1126/science.1074501",
language = "English (US)",
volume = "297",
pages = "2260--2263",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5590",

}

TY - JOUR

T1 - Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")

AU - Ricaurte, George

AU - Yuan, Jie

AU - Hatzidimitriou, George

AU - Cord, Branden J.

AU - McCann, Una D

PY - 2002/9/27

Y1 - 2002/9/27

N2 - The prevailing view is that the popular recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.

AB - The prevailing view is that the popular recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") is a selective serotonin neurotoxin in animals and possibly in humans. Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurotoxicity. MDMA neurotoxicity was associated with increased vulnerability to motor dysfunction secondary to dopamine depletion. These results have implications for mechanisms of MDMA neurotoxicity and suggest that recreational MDMA users may unwittingly be putting themselves at risk, either as young adults or later in life, for developing neuropsychiatric disorders related to brain dopamine and/or serotonin deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0037183866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037183866&partnerID=8YFLogxK

U2 - 10.1126/science.1074501

DO - 10.1126/science.1074501

M3 - Article

C2 - 12351788

AN - SCOPUS:0037183866

VL - 297

SP - 2260

EP - 2263

JO - Science

JF - Science

SN - 0036-8075

IS - 5590

ER -