Seventy years of tuberculosis prevention: Efficacy, effectiveness, toxicity, durability, and duration

Research output: Contribution to journalReview article

Abstract

Tuberculosis (TB) has been a leading infectious cause of death worldwide for much of human history, with 1.6 million deaths estimated in 2017. The Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health has played an important role in understanding and responding to TB, and it has made particularly substantial contributions to prevention of TB with chemoprophylaxis. TB preventive therapy is highly efficacious in the prevention of TB disease, yet it remains underutilized by TB programs worldwide despite strong evidence to support its use in high-risk groups, such as people living with HIV and household contacts, including those under 5 years of age. We review the evidence for TB preventive therapy and discuss the future of TB prevention.

Original languageEnglish (US)
Pages (from-to)2078-2085
Number of pages8
JournalAmerican journal of epidemiology
Volume188
Issue number12
DOIs
StatePublished - Dec 31 2019

Keywords

  • TB preventive therapy (TPT)
  • prevention
  • tuberculosis

ASJC Scopus subject areas

  • Epidemiology

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