Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles, Gianluca Severi, Johanna Schleutker, Maren Weischer, Daniele Campa, Elio Riboli, Tim Key, Henrik Gronberg, David J. Hunter, Peter Kraft, Michael J. Thun, Sue Ingles, Stephen Chanock, Demetrius Albanes, Richard B. Hayes, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan & 111 others Paul Pharoah, Fredrick Schumacher, Brian E. Henderson, Janet L. Stanford, Elaine A. Ostrander, Karina Dalsgaard Sorensen, Thilo Dörk, Gerald Andriole, Joanne L. Dickinson, Cezary Cybulski, Jan Lubinski, Amanda Spurdle, Judith A. Clements, Suzanne Chambers, Joanne Aitken, R. A Frank Gardiner, Stephen N. Thibodeau, Dan Schaid, Esther M. John, Christiane Maier, Walther Vogel, Kathleen A. Cooney, Jong Y. Park, Lisa Cannon-Albright, Hermann Brenner, Tomonori Habuchi, Hong Wei Zhang, Yong Jie Lu, Radka Kaneva, Ken Muir, Sara Benlloch, Daniel A. Leongamornlert, Edward J. Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Aritaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas R. English, Tiina Wahlfors, Teuvo L J Tammela, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Anne Tybjarg-Hansen, Stig E. Bojesen, Ruth Travis, Federico Canzian, Rudolf Kaaks, Fredrik Wiklund, Markus Aly, Sara Lindstrom, W. Ryan Diver, Susan Gapstur, Mariana C. Stern, Roman Corral, Jarmo Virtamo, Angela Cox, Christopher A. Haiman, Loic Le Marchand, Liesel Fitzgerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Ørntoft, Michael Borre, Andreas Meyer, Jürgen Serth, Meredith Yeager, Sonja I. Berndt, James R. Marthick, Briony Patterson, Dominika Wokolorczyk, Jyotsna Batra, Felicity Lose, Shannon K. McDonnell, Amit D. Joshi, Ahva Shahabi, Antje E. Rinckleb, Ana Ray, Thomas A. Sellers, Hui Yi Lin, Robert A. Stephenson, James Farnham, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang Wen Cao, Chavdar Slavov, Vanio Mitev, Douglas F. Easton, Rosalind A. Eeles

Research output: Contribution to journalArticle

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10-8 to P = 2.7 × 10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining 425% of the familial risk in this disease, have now been identified.

Original languageEnglish (US)
Pages (from-to)785-791
Number of pages7
JournalNature Genetics
Volume43
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Genome-Wide Association Study
Prostatic Neoplasms
Single Nucleotide Polymorphism
Developed Countries
Neoplasms
Chromosomes
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

Kote-Jarai, Z., Olama, A. A. A., Giles, G. G., Severi, G., Schleutker, J., Weischer, M., ... Eeles, R. A. (2011). Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics, 43(8), 785-791. https://doi.org/10.1038/ng.882

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. / Kote-Jarai, Zsofia; Olama, Ali Amin Al; Giles, Graham G.; Severi, Gianluca; Schleutker, Johanna; Weischer, Maren; Campa, Daniele; Riboli, Elio; Key, Tim; Gronberg, Henrik; Hunter, David J.; Kraft, Peter; Thun, Michael J.; Ingles, Sue; Chanock, Stephen; Albanes, Demetrius; Hayes, Richard B.; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Pharoah, Paul; Schumacher, Fredrick; Henderson, Brian E.; Stanford, Janet L.; Ostrander, Elaine A.; Sorensen, Karina Dalsgaard; Dörk, Thilo; Andriole, Gerald; Dickinson, Joanne L.; Cybulski, Cezary; Lubinski, Jan; Spurdle, Amanda; Clements, Judith A.; Chambers, Suzanne; Aitken, Joanne; Gardiner, R. A Frank; Thibodeau, Stephen N.; Schaid, Dan; John, Esther M.; Maier, Christiane; Vogel, Walther; Cooney, Kathleen A.; Park, Jong Y.; Cannon-Albright, Lisa; Brenner, Hermann; Habuchi, Tomonori; Zhang, Hong Wei; Lu, Yong Jie; Kaneva, Radka; Muir, Ken; Benlloch, Sara; Leongamornlert, Daniel A.; Saunders, Edward J.; Tymrakiewicz, Malgorzata; Mahmud, Nadiya; Guy, Michelle; O'Brien, Lynne T.; Wilkinson, Rosemary A.; Hall, Amanda L.; Sawyer, Emma J.; Dadaev, Tokhir; Morrison, Jonathan; Dearnaley, David P.; Horwich, Alan; Huddart, Robert A.; Khoo, Vincent S.; Parker, Christopher C.; Van As, Nicholas; Woodhouse, Christopher J.; Thompson, Alan; Christmas, Tim; Ogden, Chris; Cooper, Colin S.; Lophatonanon, Aritaya; Southey, Melissa C.; Hopper, John L.; English, Dallas R.; Wahlfors, Tiina; Tammela, Teuvo L J; Klarskov, Peter; Nordestgaard, Børge G.; Røder, M. Andreas; Tybjarg-Hansen, Anne; Bojesen, Stig E.; Travis, Ruth; Canzian, Federico; Kaaks, Rudolf; Wiklund, Fredrik; Aly, Markus; Lindstrom, Sara; Diver, W. Ryan; Gapstur, Susan; Stern, Mariana C.; Corral, Roman; Virtamo, Jarmo; Cox, Angela; Haiman, Christopher A.; Le Marchand, Loic; Fitzgerald, Liesel; Kolb, Suzanne; Kwon, Erika M.; Karyadi, Danielle M.; Ørntoft, Torben Falck; Borre, Michael; Meyer, Andreas; Serth, Jürgen; Yeager, Meredith; Berndt, Sonja I.; Marthick, James R.; Patterson, Briony; Wokolorczyk, Dominika; Batra, Jyotsna; Lose, Felicity; McDonnell, Shannon K.; Joshi, Amit D.; Shahabi, Ahva; Rinckleb, Antje E.; Ray, Ana; Sellers, Thomas A.; Lin, Hui Yi; Stephenson, Robert A.; Farnham, James; Muller, Heiko; Rothenbacher, Dietrich; Tsuchiya, Norihiko; Narita, Shintaro; Cao, Guang Wen; Slavov, Chavdar; Mitev, Vanio; Easton, Douglas F.; Eeles, Rosalind A.

In: Nature Genetics, Vol. 43, No. 8, 08.2011, p. 785-791.

Research output: Contribution to journalArticle

Kote-Jarai, Z, Olama, AAA, Giles, GG, Severi, G, Schleutker, J, Weischer, M, Campa, D, Riboli, E, Key, T, Gronberg, H, Hunter, DJ, Kraft, P, Thun, MJ, Ingles, S, Chanock, S, Albanes, D, Hayes, RB, Neal, DE, Hamdy, FC, Donovan, JL, Pharoah, P, Schumacher, F, Henderson, BE, Stanford, JL, Ostrander, EA, Sorensen, KD, Dörk, T, Andriole, G, Dickinson, JL, Cybulski, C, Lubinski, J, Spurdle, A, Clements, JA, Chambers, S, Aitken, J, Gardiner, RAF, Thibodeau, SN, Schaid, D, John, EM, Maier, C, Vogel, W, Cooney, KA, Park, JY, Cannon-Albright, L, Brenner, H, Habuchi, T, Zhang, HW, Lu, YJ, Kaneva, R, Muir, K, Benlloch, S, Leongamornlert, DA, Saunders, EJ, Tymrakiewicz, M, Mahmud, N, Guy, M, O'Brien, LT, Wilkinson, RA, Hall, AL, Sawyer, EJ, Dadaev, T, Morrison, J, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Lophatonanon, A, Southey, MC, Hopper, JL, English, DR, Wahlfors, T, Tammela, TLJ, Klarskov, P, Nordestgaard, BG, Røder, MA, Tybjarg-Hansen, A, Bojesen, SE, Travis, R, Canzian, F, Kaaks, R, Wiklund, F, Aly, M, Lindstrom, S, Diver, WR, Gapstur, S, Stern, MC, Corral, R, Virtamo, J, Cox, A, Haiman, CA, Le Marchand, L, Fitzgerald, L, Kolb, S, Kwon, EM, Karyadi, DM, Ørntoft, TF, Borre, M, Meyer, A, Serth, J, Yeager, M, Berndt, SI, Marthick, JR, Patterson, B, Wokolorczyk, D, Batra, J, Lose, F, McDonnell, SK, Joshi, AD, Shahabi, A, Rinckleb, AE, Ray, A, Sellers, TA, Lin, HY, Stephenson, RA, Farnham, J, Muller, H, Rothenbacher, D, Tsuchiya, N, Narita, S, Cao, GW, Slavov, C, Mitev, V, Easton, DF & Eeles, RA 2011, 'Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study', Nature Genetics, vol. 43, no. 8, pp. 785-791. https://doi.org/10.1038/ng.882
Kote-Jarai Z, Olama AAA, Giles GG, Severi G, Schleutker J, Weischer M et al. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics. 2011 Aug;43(8):785-791. https://doi.org/10.1038/ng.882
Kote-Jarai, Zsofia ; Olama, Ali Amin Al ; Giles, Graham G. ; Severi, Gianluca ; Schleutker, Johanna ; Weischer, Maren ; Campa, Daniele ; Riboli, Elio ; Key, Tim ; Gronberg, Henrik ; Hunter, David J. ; Kraft, Peter ; Thun, Michael J. ; Ingles, Sue ; Chanock, Stephen ; Albanes, Demetrius ; Hayes, Richard B. ; Neal, David E. ; Hamdy, Freddie C. ; Donovan, Jenny L. ; Pharoah, Paul ; Schumacher, Fredrick ; Henderson, Brian E. ; Stanford, Janet L. ; Ostrander, Elaine A. ; Sorensen, Karina Dalsgaard ; Dörk, Thilo ; Andriole, Gerald ; Dickinson, Joanne L. ; Cybulski, Cezary ; Lubinski, Jan ; Spurdle, Amanda ; Clements, Judith A. ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, R. A Frank ; Thibodeau, Stephen N. ; Schaid, Dan ; John, Esther M. ; Maier, Christiane ; Vogel, Walther ; Cooney, Kathleen A. ; Park, Jong Y. ; Cannon-Albright, Lisa ; Brenner, Hermann ; Habuchi, Tomonori ; Zhang, Hong Wei ; Lu, Yong Jie ; Kaneva, Radka ; Muir, Ken ; Benlloch, Sara ; Leongamornlert, Daniel A. ; Saunders, Edward J. ; Tymrakiewicz, Malgorzata ; Mahmud, Nadiya ; Guy, Michelle ; O'Brien, Lynne T. ; Wilkinson, Rosemary A. ; Hall, Amanda L. ; Sawyer, Emma J. ; Dadaev, Tokhir ; Morrison, Jonathan ; Dearnaley, David P. ; Horwich, Alan ; Huddart, Robert A. ; Khoo, Vincent S. ; Parker, Christopher C. ; Van As, Nicholas ; Woodhouse, Christopher J. ; Thompson, Alan ; Christmas, Tim ; Ogden, Chris ; Cooper, Colin S. ; Lophatonanon, Aritaya ; Southey, Melissa C. ; Hopper, John L. ; English, Dallas R. ; Wahlfors, Tiina ; Tammela, Teuvo L J ; Klarskov, Peter ; Nordestgaard, Børge G. ; Røder, M. Andreas ; Tybjarg-Hansen, Anne ; Bojesen, Stig E. ; Travis, Ruth ; Canzian, Federico ; Kaaks, Rudolf ; Wiklund, Fredrik ; Aly, Markus ; Lindstrom, Sara ; Diver, W. Ryan ; Gapstur, Susan ; Stern, Mariana C. ; Corral, Roman ; Virtamo, Jarmo ; Cox, Angela ; Haiman, Christopher A. ; Le Marchand, Loic ; Fitzgerald, Liesel ; Kolb, Suzanne ; Kwon, Erika M. ; Karyadi, Danielle M. ; Ørntoft, Torben Falck ; Borre, Michael ; Meyer, Andreas ; Serth, Jürgen ; Yeager, Meredith ; Berndt, Sonja I. ; Marthick, James R. ; Patterson, Briony ; Wokolorczyk, Dominika ; Batra, Jyotsna ; Lose, Felicity ; McDonnell, Shannon K. ; Joshi, Amit D. ; Shahabi, Ahva ; Rinckleb, Antje E. ; Ray, Ana ; Sellers, Thomas A. ; Lin, Hui Yi ; Stephenson, Robert A. ; Farnham, James ; Muller, Heiko ; Rothenbacher, Dietrich ; Tsuchiya, Norihiko ; Narita, Shintaro ; Cao, Guang Wen ; Slavov, Chavdar ; Mitev, Vanio ; Easton, Douglas F. ; Eeles, Rosalind A. / Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. In: Nature Genetics. 2011 ; Vol. 43, No. 8. pp. 785-791.
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abstract = "Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10-8 to P = 2.7 × 10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining 425{\%} of the familial risk in this disease, have now been identified.",
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T1 - Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

AU - Kote-Jarai, Zsofia

AU - Olama, Ali Amin Al

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Campa, Daniele

AU - Riboli, Elio

AU - Key, Tim

AU - Gronberg, Henrik

AU - Hunter, David J.

AU - Kraft, Peter

AU - Thun, Michael J.

AU - Ingles, Sue

AU - Chanock, Stephen

AU - Albanes, Demetrius

AU - Hayes, Richard B.

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Pharoah, Paul

AU - Schumacher, Fredrick

AU - Henderson, Brian E.

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Sorensen, Karina Dalsgaard

AU - Dörk, Thilo

AU - Andriole, Gerald

AU - Dickinson, Joanne L.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Spurdle, Amanda

AU - Clements, Judith A.

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, R. A Frank

AU - Thibodeau, Stephen N.

AU - Schaid, Dan

AU - John, Esther M.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Cooney, Kathleen A.

AU - Park, Jong Y.

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Habuchi, Tomonori

AU - Zhang, Hong Wei

AU - Lu, Yong Jie

AU - Kaneva, Radka

AU - Muir, Ken

AU - Benlloch, Sara

AU - Leongamornlert, Daniel A.

AU - Saunders, Edward J.

AU - Tymrakiewicz, Malgorzata

AU - Mahmud, Nadiya

AU - Guy, Michelle

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Hall, Amanda L.

AU - Sawyer, Emma J.

AU - Dadaev, Tokhir

AU - Morrison, Jonathan

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Lophatonanon, Aritaya

AU - Southey, Melissa C.

AU - Hopper, John L.

AU - English, Dallas R.

AU - Wahlfors, Tiina

AU - Tammela, Teuvo L J

AU - Klarskov, Peter

AU - Nordestgaard, Børge G.

AU - Røder, M. Andreas

AU - Tybjarg-Hansen, Anne

AU - Bojesen, Stig E.

AU - Travis, Ruth

AU - Canzian, Federico

AU - Kaaks, Rudolf

AU - Wiklund, Fredrik

AU - Aly, Markus

AU - Lindstrom, Sara

AU - Diver, W. Ryan

AU - Gapstur, Susan

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Virtamo, Jarmo

AU - Cox, Angela

AU - Haiman, Christopher A.

AU - Le Marchand, Loic

AU - Fitzgerald, Liesel

AU - Kolb, Suzanne

AU - Kwon, Erika M.

AU - Karyadi, Danielle M.

AU - Ørntoft, Torben Falck

AU - Borre, Michael

AU - Meyer, Andreas

AU - Serth, Jürgen

AU - Yeager, Meredith

AU - Berndt, Sonja I.

AU - Marthick, James R.

AU - Patterson, Briony

AU - Wokolorczyk, Dominika

AU - Batra, Jyotsna

AU - Lose, Felicity

AU - McDonnell, Shannon K.

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - Rinckleb, Antje E.

AU - Ray, Ana

AU - Sellers, Thomas A.

AU - Lin, Hui Yi

AU - Stephenson, Robert A.

AU - Farnham, James

AU - Muller, Heiko

AU - Rothenbacher, Dietrich

AU - Tsuchiya, Norihiko

AU - Narita, Shintaro

AU - Cao, Guang Wen

AU - Slavov, Chavdar

AU - Mitev, Vanio

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

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N2 - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10-8 to P = 2.7 × 10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining 425% of the familial risk in this disease, have now been identified.

AB - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10-8 to P = 2.7 × 10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining 425% of the familial risk in this disease, have now been identified.

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