Setting an agenda for comparative effectiveness systematic reviews in CKD care

Deidra C. Crews, Raquel C. Greer, Jeffrey J. Fadrowski, Michael J. Choi, David Doggett, Jodi B. Segal, Kemi A. Fawole, Pammie R. Crawford, L. Ebony Boulware

Research output: Contribution to journalArticlepeer-review


Systematic reviews comparing the effectiveness of strategies to prevent, detect, and treat chronic kidney disease are needed to inform patient care. We engaged stakeholders in the chronic kidney disease community to prioritize topics for future comparative effectiveness research systematic reviews. We developed a preliminary list of suggested topics and stakeholders refined and ranked topics based on their importance. Among 46 topics identified, stakeholders nominated 18 as high priority. Most pertained to strategies to slow disease progression, including: (a) treat proteinuria, (b) improve access to care, (c) treat hypertension, (d) use health information technology, and (e) implement dietary strategies. Most (15 of 18) topics had been previously studied with two or more randomized controlled trials, indicating feasibility of rigorous systematic reviews. Chronic kidney disease topics rated by stakeholders as high priority are varied in scope and may lead to quality systematic reviews impacting practice and policy.

Original languageEnglish (US)
Article number74
JournalBMC nephrology
Issue number1
StatePublished - 2012


  • Chronic kidney disease
  • Evidence-based practice
  • Health services research

ASJC Scopus subject areas

  • Nephrology


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