Services and prevention: Pharmacoepidemiology of antidepressant use

Julie Magno Zito, Daniel J. Safer

Research output: Contribution to journalArticle

Abstract

Between 1988 and 1994, data from 3 large sites revealed a 3-5 fold increase in the prevalence of antidepressant (ATD) treatment for U.S. youths aged 2-19 years. In 1994, the ATD prevalence for youths of this age ranged from 13 per 1000 (in the HMO) to 18 per 1000 (in 2 state Medicaid systems). Males predominated in the 10-14-year-olds treated with ATDs, whereas females predominated among 15-19-year-olds. Caucasians were more than twice as likely to receive ATD therapy than their African-American counterparts. Primary care providers were the major source of ATD prescriptions for youths. The leading diagnoses in primary care were ADHD followed by depression, whereas the diagnostic order was reversed for youths who received psychiatric services. This review provides details concerning these patterns and trends in ATD treatment of youths from community-based clinical data sources. In addition, the role of these data in an expanded, comprehensive psychotropic knowledge base is discussed. Finally, the implications of an expanded knowledge base for ATD treatments are discussed in regard to generating research questions on effectiveness and safety and to improve treatment consensus within a public-health perspective.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalBiological Psychiatry
Volume49
Issue number12
DOIs
StatePublished - Jun 15 2001

Fingerprint

Pharmacoepidemiology
Antidepressive Agents
Knowledge Bases
Primary Health Care
Therapeutics
Health Maintenance Organizations
Information Storage and Retrieval
Medicaid
African Americans
Prescriptions
Psychiatry
Public Health
Safety
Research

Keywords

  • Antidepressants
  • Child and adolescent psychopharmacology
  • Consensus development
  • Mental health services
  • Pharmacoepidemiology

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Services and prevention : Pharmacoepidemiology of antidepressant use. / Zito, Julie Magno; Safer, Daniel J.

In: Biological Psychiatry, Vol. 49, No. 12, 15.06.2001, p. 1121-1127.

Research output: Contribution to journalArticle

@article{e062b136a9854f81a7f72338ea121a01,
title = "Services and prevention: Pharmacoepidemiology of antidepressant use",
abstract = "Between 1988 and 1994, data from 3 large sites revealed a 3-5 fold increase in the prevalence of antidepressant (ATD) treatment for U.S. youths aged 2-19 years. In 1994, the ATD prevalence for youths of this age ranged from 13 per 1000 (in the HMO) to 18 per 1000 (in 2 state Medicaid systems). Males predominated in the 10-14-year-olds treated with ATDs, whereas females predominated among 15-19-year-olds. Caucasians were more than twice as likely to receive ATD therapy than their African-American counterparts. Primary care providers were the major source of ATD prescriptions for youths. The leading diagnoses in primary care were ADHD followed by depression, whereas the diagnostic order was reversed for youths who received psychiatric services. This review provides details concerning these patterns and trends in ATD treatment of youths from community-based clinical data sources. In addition, the role of these data in an expanded, comprehensive psychotropic knowledge base is discussed. Finally, the implications of an expanded knowledge base for ATD treatments are discussed in regard to generating research questions on effectiveness and safety and to improve treatment consensus within a public-health perspective.",
keywords = "Antidepressants, Child and adolescent psychopharmacology, Consensus development, Mental health services, Pharmacoepidemiology",
author = "Zito, {Julie Magno} and Safer, {Daniel J.}",
year = "2001",
month = "6",
day = "15",
doi = "10.1016/S0006-3223(01)01174-X",
language = "English (US)",
volume = "49",
pages = "1121--1127",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "12",

}

TY - JOUR

T1 - Services and prevention

T2 - Pharmacoepidemiology of antidepressant use

AU - Zito, Julie Magno

AU - Safer, Daniel J.

PY - 2001/6/15

Y1 - 2001/6/15

N2 - Between 1988 and 1994, data from 3 large sites revealed a 3-5 fold increase in the prevalence of antidepressant (ATD) treatment for U.S. youths aged 2-19 years. In 1994, the ATD prevalence for youths of this age ranged from 13 per 1000 (in the HMO) to 18 per 1000 (in 2 state Medicaid systems). Males predominated in the 10-14-year-olds treated with ATDs, whereas females predominated among 15-19-year-olds. Caucasians were more than twice as likely to receive ATD therapy than their African-American counterparts. Primary care providers were the major source of ATD prescriptions for youths. The leading diagnoses in primary care were ADHD followed by depression, whereas the diagnostic order was reversed for youths who received psychiatric services. This review provides details concerning these patterns and trends in ATD treatment of youths from community-based clinical data sources. In addition, the role of these data in an expanded, comprehensive psychotropic knowledge base is discussed. Finally, the implications of an expanded knowledge base for ATD treatments are discussed in regard to generating research questions on effectiveness and safety and to improve treatment consensus within a public-health perspective.

AB - Between 1988 and 1994, data from 3 large sites revealed a 3-5 fold increase in the prevalence of antidepressant (ATD) treatment for U.S. youths aged 2-19 years. In 1994, the ATD prevalence for youths of this age ranged from 13 per 1000 (in the HMO) to 18 per 1000 (in 2 state Medicaid systems). Males predominated in the 10-14-year-olds treated with ATDs, whereas females predominated among 15-19-year-olds. Caucasians were more than twice as likely to receive ATD therapy than their African-American counterparts. Primary care providers were the major source of ATD prescriptions for youths. The leading diagnoses in primary care were ADHD followed by depression, whereas the diagnostic order was reversed for youths who received psychiatric services. This review provides details concerning these patterns and trends in ATD treatment of youths from community-based clinical data sources. In addition, the role of these data in an expanded, comprehensive psychotropic knowledge base is discussed. Finally, the implications of an expanded knowledge base for ATD treatments are discussed in regard to generating research questions on effectiveness and safety and to improve treatment consensus within a public-health perspective.

KW - Antidepressants

KW - Child and adolescent psychopharmacology

KW - Consensus development

KW - Mental health services

KW - Pharmacoepidemiology

UR - http://www.scopus.com/inward/record.url?scp=0035875148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035875148&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(01)01174-X

DO - 10.1016/S0006-3223(01)01174-X

M3 - Article

C2 - 11430854

AN - SCOPUS:0035875148

VL - 49

SP - 1121

EP - 1127

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 12

ER -