Serum Vitamin Levels and the Risk of Asthma in Children

Raida I. Harik-Khan, Denis C. Muller, Robert A Wise

Research output: Contribution to journalArticle

Abstract

Dietary intake, especially of antioxidant vitamins A, C, E, and the carotenoids, has been linked with the presence and severity of asthma. From the Third National Health and Nutrition Examination Survey (NHANES III), conducted in the United States between 1988 and 1994, the authors selected 4,093 children (aged 6-17 years) for whom relevant medical, socioeconomic, and anthropometric data were complete. The children were 50.6% female, and 9.7% reported a diagnosis of asthma. Bivariate analyses showed that asthma diagnosis was associated with lower levels of serum vitamin C, α-carotene, β-carotene, and β-cryptoxanthin. However, antioxidant levels may be surrogate markers for socioeconomic variables such as race, poverty, tobacco exposure, or general nutritional status. In logistic models that included age, body mass index, socioeconomic variables, antioxidant levels, parental asthma, and household smoking, the only antioxidants significantly associated with asthma were vitamin C (odds ratio = 0.72 per mg/dl, 95% confidence interval = 0.55, 0.95) and α-carotene (odds ratio = 0.95 per μg/dl, 95% confidence interval = 0.90, 0.99). The odds ratio for asthma in the highest quintile of serum vitamin C relative to the lowest was 0.65 (p <0.05), whereas it was 0.74 for α-carotene (p = 0.066). The authors concluded that low vitamin C and α-carotene intakes are associated with asthma risk in children.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalAmerican Journal of Epidemiology
Volume159
Issue number4
DOIs
StatePublished - Feb 15 2004

Fingerprint

Vitamins
Carotenoids
Asthma
Ascorbic Acid
Serum
Antioxidants
Nutrition Surveys
Odds Ratio
Confidence Intervals
Poverty
Nutritional Status
Vitamin A
Tobacco
Body Mass Index
Biomarkers
Logistic Models
Smoking

Keywords

  • Adolescent
  • Antioxidants
  • Ascorbic acid
  • Asthma
  • Child

ASJC Scopus subject areas

  • Epidemiology

Cite this

Serum Vitamin Levels and the Risk of Asthma in Children. / Harik-Khan, Raida I.; Muller, Denis C.; Wise, Robert A.

In: American Journal of Epidemiology, Vol. 159, No. 4, 15.02.2004, p. 351-357.

Research output: Contribution to journalArticle

Harik-Khan, Raida I. ; Muller, Denis C. ; Wise, Robert A. / Serum Vitamin Levels and the Risk of Asthma in Children. In: American Journal of Epidemiology. 2004 ; Vol. 159, No. 4. pp. 351-357.
@article{e3d2d3f3ca10403bb83a6863b5bbc6b3,
title = "Serum Vitamin Levels and the Risk of Asthma in Children",
abstract = "Dietary intake, especially of antioxidant vitamins A, C, E, and the carotenoids, has been linked with the presence and severity of asthma. From the Third National Health and Nutrition Examination Survey (NHANES III), conducted in the United States between 1988 and 1994, the authors selected 4,093 children (aged 6-17 years) for whom relevant medical, socioeconomic, and anthropometric data were complete. The children were 50.6{\%} female, and 9.7{\%} reported a diagnosis of asthma. Bivariate analyses showed that asthma diagnosis was associated with lower levels of serum vitamin C, α-carotene, β-carotene, and β-cryptoxanthin. However, antioxidant levels may be surrogate markers for socioeconomic variables such as race, poverty, tobacco exposure, or general nutritional status. In logistic models that included age, body mass index, socioeconomic variables, antioxidant levels, parental asthma, and household smoking, the only antioxidants significantly associated with asthma were vitamin C (odds ratio = 0.72 per mg/dl, 95{\%} confidence interval = 0.55, 0.95) and α-carotene (odds ratio = 0.95 per μg/dl, 95{\%} confidence interval = 0.90, 0.99). The odds ratio for asthma in the highest quintile of serum vitamin C relative to the lowest was 0.65 (p <0.05), whereas it was 0.74 for α-carotene (p = 0.066). The authors concluded that low vitamin C and α-carotene intakes are associated with asthma risk in children.",
keywords = "Adolescent, Antioxidants, Ascorbic acid, Asthma, Child",
author = "Harik-Khan, {Raida I.} and Muller, {Denis C.} and Wise, {Robert A}",
year = "2004",
month = "2",
day = "15",
doi = "10.1093/aje/kwh053",
language = "English (US)",
volume = "159",
pages = "351--357",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Serum Vitamin Levels and the Risk of Asthma in Children

AU - Harik-Khan, Raida I.

AU - Muller, Denis C.

AU - Wise, Robert A

PY - 2004/2/15

Y1 - 2004/2/15

N2 - Dietary intake, especially of antioxidant vitamins A, C, E, and the carotenoids, has been linked with the presence and severity of asthma. From the Third National Health and Nutrition Examination Survey (NHANES III), conducted in the United States between 1988 and 1994, the authors selected 4,093 children (aged 6-17 years) for whom relevant medical, socioeconomic, and anthropometric data were complete. The children were 50.6% female, and 9.7% reported a diagnosis of asthma. Bivariate analyses showed that asthma diagnosis was associated with lower levels of serum vitamin C, α-carotene, β-carotene, and β-cryptoxanthin. However, antioxidant levels may be surrogate markers for socioeconomic variables such as race, poverty, tobacco exposure, or general nutritional status. In logistic models that included age, body mass index, socioeconomic variables, antioxidant levels, parental asthma, and household smoking, the only antioxidants significantly associated with asthma were vitamin C (odds ratio = 0.72 per mg/dl, 95% confidence interval = 0.55, 0.95) and α-carotene (odds ratio = 0.95 per μg/dl, 95% confidence interval = 0.90, 0.99). The odds ratio for asthma in the highest quintile of serum vitamin C relative to the lowest was 0.65 (p <0.05), whereas it was 0.74 for α-carotene (p = 0.066). The authors concluded that low vitamin C and α-carotene intakes are associated with asthma risk in children.

AB - Dietary intake, especially of antioxidant vitamins A, C, E, and the carotenoids, has been linked with the presence and severity of asthma. From the Third National Health and Nutrition Examination Survey (NHANES III), conducted in the United States between 1988 and 1994, the authors selected 4,093 children (aged 6-17 years) for whom relevant medical, socioeconomic, and anthropometric data were complete. The children were 50.6% female, and 9.7% reported a diagnosis of asthma. Bivariate analyses showed that asthma diagnosis was associated with lower levels of serum vitamin C, α-carotene, β-carotene, and β-cryptoxanthin. However, antioxidant levels may be surrogate markers for socioeconomic variables such as race, poverty, tobacco exposure, or general nutritional status. In logistic models that included age, body mass index, socioeconomic variables, antioxidant levels, parental asthma, and household smoking, the only antioxidants significantly associated with asthma were vitamin C (odds ratio = 0.72 per mg/dl, 95% confidence interval = 0.55, 0.95) and α-carotene (odds ratio = 0.95 per μg/dl, 95% confidence interval = 0.90, 0.99). The odds ratio for asthma in the highest quintile of serum vitamin C relative to the lowest was 0.65 (p <0.05), whereas it was 0.74 for α-carotene (p = 0.066). The authors concluded that low vitamin C and α-carotene intakes are associated with asthma risk in children.

KW - Adolescent

KW - Antioxidants

KW - Ascorbic acid

KW - Asthma

KW - Child

UR - http://www.scopus.com/inward/record.url?scp=1042265095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1042265095&partnerID=8YFLogxK

U2 - 10.1093/aje/kwh053

DO - 10.1093/aje/kwh053

M3 - Article

VL - 159

SP - 351

EP - 357

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 4

ER -