Serum vitamin E concentrations and recovery of physical function during the year after hip fracture

Christopher R. D'Adamo, Ram R. Miller, Gregory E. Hicks, Denise L. Orwig, Marc C. Hochberg, Richard David Semba, Janet A. Yu-Yahiro, Luigi Ferrucci, Jay Magaziner, Michelle D. Shardell

Research output: Contribution to journalArticle

Abstract

Background. Poor nutritional status after hip fracture is common and may contribute to physical function decline. Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored. Methods. Serum concentrations of α- and γ-tocopherol, the two major forms of vitamin E, were measured in female hip fracture patients from the Baltimore Hip Studies cohort 4 at baseline and at 2-, 6-, and 12-month postfracture follow-up visits. Four physical function measures-Six-Minute Walk Distance, Lower Extremity Gain Scale, Short Form-36 Physical Functioning Domain, and Yale Physical Activity Survey-were assessed at 2, 6, and 12 months postfracture. Generalized estimating equations modeled the relationship between baseline and time-varying serum tocopherol concentrations and physical function after hip fracture. Results. A total of 148 women aged 65 years and older were studied. After adjusting for covariates, baseline vitamin E concentrations were positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, and Yale Physical Activity Survey scores (p <.1) and faster improvement in Lower Extremity Gain Scale and Yale Physical Activity Survey scores (p <.008). Time-varying vitamin E was also positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, Yale Physical Activity Survey, and Short Form-36 Physical Functioning Domain (p <.03) and faster improvement in Six-Minute Walk Distance and Short Form-36 Physical Functioning Domain (p <.07). Conclusions. Serum concentrations of both α- and γ-tocopherol were associated with better physical function after hip fracture. Vitamin E may represent a potentially modifiable factor related to recovery of postfracture physical function.

Original languageEnglish (US)
Pages (from-to)784-793
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume66 A
Issue number7
DOIs
StatePublished - Jul 2011

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Recovery of Function
Hip Fractures
Vitamin E
Tocopherols
Lower Extremity
Serum
Exercise
Baltimore
Nutritional Status
Hip
Cohort Studies
Surveys and Questionnaires

Keywords

  • Hip fracture
  • Micronutrients
  • Nutrition
  • Physical function
  • Vitamin E

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Serum vitamin E concentrations and recovery of physical function during the year after hip fracture. / D'Adamo, Christopher R.; Miller, Ram R.; Hicks, Gregory E.; Orwig, Denise L.; Hochberg, Marc C.; Semba, Richard David; Yu-Yahiro, Janet A.; Ferrucci, Luigi; Magaziner, Jay; Shardell, Michelle D.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 66 A, No. 7, 07.2011, p. 784-793.

Research output: Contribution to journalArticle

D'Adamo, CR, Miller, RR, Hicks, GE, Orwig, DL, Hochberg, MC, Semba, RD, Yu-Yahiro, JA, Ferrucci, L, Magaziner, J & Shardell, MD 2011, 'Serum vitamin E concentrations and recovery of physical function during the year after hip fracture', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, no. 7, pp. 784-793. https://doi.org/10.1093/gerona/glr057
D'Adamo, Christopher R. ; Miller, Ram R. ; Hicks, Gregory E. ; Orwig, Denise L. ; Hochberg, Marc C. ; Semba, Richard David ; Yu-Yahiro, Janet A. ; Ferrucci, Luigi ; Magaziner, Jay ; Shardell, Michelle D. / Serum vitamin E concentrations and recovery of physical function during the year after hip fracture. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2011 ; Vol. 66 A, No. 7. pp. 784-793.
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abstract = "Background. Poor nutritional status after hip fracture is common and may contribute to physical function decline. Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored. Methods. Serum concentrations of α- and γ-tocopherol, the two major forms of vitamin E, were measured in female hip fracture patients from the Baltimore Hip Studies cohort 4 at baseline and at 2-, 6-, and 12-month postfracture follow-up visits. Four physical function measures-Six-Minute Walk Distance, Lower Extremity Gain Scale, Short Form-36 Physical Functioning Domain, and Yale Physical Activity Survey-were assessed at 2, 6, and 12 months postfracture. Generalized estimating equations modeled the relationship between baseline and time-varying serum tocopherol concentrations and physical function after hip fracture. Results. A total of 148 women aged 65 years and older were studied. After adjusting for covariates, baseline vitamin E concentrations were positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, and Yale Physical Activity Survey scores (p <.1) and faster improvement in Lower Extremity Gain Scale and Yale Physical Activity Survey scores (p <.008). Time-varying vitamin E was also positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, Yale Physical Activity Survey, and Short Form-36 Physical Functioning Domain (p <.03) and faster improvement in Six-Minute Walk Distance and Short Form-36 Physical Functioning Domain (p <.07). Conclusions. Serum concentrations of both α- and γ-tocopherol were associated with better physical function after hip fracture. Vitamin E may represent a potentially modifiable factor related to recovery of postfracture physical function.",
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T1 - Serum vitamin E concentrations and recovery of physical function during the year after hip fracture

AU - D'Adamo, Christopher R.

AU - Miller, Ram R.

AU - Hicks, Gregory E.

AU - Orwig, Denise L.

AU - Hochberg, Marc C.

AU - Semba, Richard David

AU - Yu-Yahiro, Janet A.

AU - Ferrucci, Luigi

AU - Magaziner, Jay

AU - Shardell, Michelle D.

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N2 - Background. Poor nutritional status after hip fracture is common and may contribute to physical function decline. Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored. Methods. Serum concentrations of α- and γ-tocopherol, the two major forms of vitamin E, were measured in female hip fracture patients from the Baltimore Hip Studies cohort 4 at baseline and at 2-, 6-, and 12-month postfracture follow-up visits. Four physical function measures-Six-Minute Walk Distance, Lower Extremity Gain Scale, Short Form-36 Physical Functioning Domain, and Yale Physical Activity Survey-were assessed at 2, 6, and 12 months postfracture. Generalized estimating equations modeled the relationship between baseline and time-varying serum tocopherol concentrations and physical function after hip fracture. Results. A total of 148 women aged 65 years and older were studied. After adjusting for covariates, baseline vitamin E concentrations were positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, and Yale Physical Activity Survey scores (p <.1) and faster improvement in Lower Extremity Gain Scale and Yale Physical Activity Survey scores (p <.008). Time-varying vitamin E was also positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, Yale Physical Activity Survey, and Short Form-36 Physical Functioning Domain (p <.03) and faster improvement in Six-Minute Walk Distance and Short Form-36 Physical Functioning Domain (p <.07). Conclusions. Serum concentrations of both α- and γ-tocopherol were associated with better physical function after hip fracture. Vitamin E may represent a potentially modifiable factor related to recovery of postfracture physical function.

AB - Background. Poor nutritional status after hip fracture is common and may contribute to physical function decline. Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored. Methods. Serum concentrations of α- and γ-tocopherol, the two major forms of vitamin E, were measured in female hip fracture patients from the Baltimore Hip Studies cohort 4 at baseline and at 2-, 6-, and 12-month postfracture follow-up visits. Four physical function measures-Six-Minute Walk Distance, Lower Extremity Gain Scale, Short Form-36 Physical Functioning Domain, and Yale Physical Activity Survey-were assessed at 2, 6, and 12 months postfracture. Generalized estimating equations modeled the relationship between baseline and time-varying serum tocopherol concentrations and physical function after hip fracture. Results. A total of 148 women aged 65 years and older were studied. After adjusting for covariates, baseline vitamin E concentrations were positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, and Yale Physical Activity Survey scores (p <.1) and faster improvement in Lower Extremity Gain Scale and Yale Physical Activity Survey scores (p <.008). Time-varying vitamin E was also positively associated with Six-Minute Walk Distance, Lower Extremity Gain Scale, Yale Physical Activity Survey, and Short Form-36 Physical Functioning Domain (p <.03) and faster improvement in Six-Minute Walk Distance and Short Form-36 Physical Functioning Domain (p <.07). Conclusions. Serum concentrations of both α- and γ-tocopherol were associated with better physical function after hip fracture. Vitamin E may represent a potentially modifiable factor related to recovery of postfracture physical function.

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