Serum uric acid levels are associated with cardiovascular risk score

A post hoc analysis of the EURIKA study

Claudio Borghi, Fernando Rodriguez-Artalejo, Guy De Backer, Jean Dallongeville, Jesús Medina, Javier Nuevo, Eliseo Guallar, Joep Perk, José R. Banegas, Florence Tubach, Carine Roy, Julian P. Halcox

Research output: Contribution to journalArticle

Abstract

Background Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (< 1%), intermediate (1% to < 5%), high (≥ 5% to < 10%) or very high (≥ 10%). Results Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95% CI: 1.34–1.44]) and all subgroups (using diuretics: 1.32 [1.24–1.40]; not using diuretics: 1.46 [1.39–1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2: 1.30 [1.22–1.38]; eGFR ≥ 60 ml/min/1.73 m2: 1.44 [1.38–1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalInternational Journal of Cardiology
Volume253
DOIs
StatePublished - Feb 15 2018

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Uric Acid
Serum
Diuretics
Glomerular Filtration Rate
Cardiovascular Diseases
Hypoglycemic Agents
Antihypertensive Agents
Population
Comorbidity
Body Mass Index
Logistic Models
Regression Analysis
Kidney
Lipids

Keywords

  • Cardiovascular risk
  • European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA)
  • Serum uric acid
  • Systematic COronary Risk Evaluation (SCORE)
  • Systematic COronary Risk Evaluation algorithm including high-density lipoprotein cholesterol (SCORE-HDL)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Borghi, C., Rodriguez-Artalejo, F., De Backer, G., Dallongeville, J., Medina, J., Nuevo, J., ... Halcox, J. P. (2018). Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. International Journal of Cardiology, 253, 167-173. https://doi.org/10.1016/j.ijcard.2017.10.045

Serum uric acid levels are associated with cardiovascular risk score : A post hoc analysis of the EURIKA study. / Borghi, Claudio; Rodriguez-Artalejo, Fernando; De Backer, Guy; Dallongeville, Jean; Medina, Jesús; Nuevo, Javier; Guallar, Eliseo; Perk, Joep; Banegas, José R.; Tubach, Florence; Roy, Carine; Halcox, Julian P.

In: International Journal of Cardiology, Vol. 253, 15.02.2018, p. 167-173.

Research output: Contribution to journalArticle

Borghi, C, Rodriguez-Artalejo, F, De Backer, G, Dallongeville, J, Medina, J, Nuevo, J, Guallar, E, Perk, J, Banegas, JR, Tubach, F, Roy, C & Halcox, JP 2018, 'Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study', International Journal of Cardiology, vol. 253, pp. 167-173. https://doi.org/10.1016/j.ijcard.2017.10.045
Borghi, Claudio ; Rodriguez-Artalejo, Fernando ; De Backer, Guy ; Dallongeville, Jean ; Medina, Jesús ; Nuevo, Javier ; Guallar, Eliseo ; Perk, Joep ; Banegas, José R. ; Tubach, Florence ; Roy, Carine ; Halcox, Julian P. / Serum uric acid levels are associated with cardiovascular risk score : A post hoc analysis of the EURIKA study. In: International Journal of Cardiology. 2018 ; Vol. 253. pp. 167-173.
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abstract = "Background Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (< 1{\%}), intermediate (1{\%} to < 5{\%}), high (≥ 5{\%} to < 10{\%}) or very high (≥ 10{\%}). Results Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95{\%} CI: 1.34–1.44]) and all subgroups (using diuretics: 1.32 [1.24–1.40]; not using diuretics: 1.46 [1.39–1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2: 1.30 [1.22–1.38]; eGFR ≥ 60 ml/min/1.73 m2: 1.44 [1.38–1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease.",
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AU - Dallongeville, Jean

AU - Medina, Jesús

AU - Nuevo, Javier

AU - Guallar, Eliseo

AU - Perk, Joep

AU - Banegas, José R.

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AU - Halcox, Julian P.

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AB - Background Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (< 1%), intermediate (1% to < 5%), high (≥ 5% to < 10%) or very high (≥ 10%). Results Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95% CI: 1.34–1.44]) and all subgroups (using diuretics: 1.32 [1.24–1.40]; not using diuretics: 1.46 [1.39–1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2: 1.30 [1.22–1.38]; eGFR ≥ 60 ml/min/1.73 m2: 1.44 [1.38–1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease.

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