Serum uric acid and brain ischemia in normal elderly adults

David Schretlen, A. B. Inscore, Tracy Vannorsdall, Michael A Kraut, G. D. Pearlson, Barry Gordon, H. A. Jinnah

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults. METHOD: In this cross-sectional, observational study, we examined the relationship between serum UA and aggregate volume of white matter hyperintense (WMH) signals observed on proton density and T2-weighted brain MR images in a community sample of 177 adults ages 20 to 92. Using logistic regression, we tested whether participants with UA concentrations in the highest quartile of the sample-but still normal-would have increased WMH volumes. RESULTS: Compared with those with low to moderate levels, participants with high normal serum UA were more likely to fall in the highest quartile of WMH volume. The odds ratios (95% CIs) of increased WMH were 2.6 (1.2 to 5.4) for total, 2.5 (1.2 to 5.1) for periventricular, and 2.8 (1.4 to 5.9) for subcortical WMH volume. After controlling for age, sex, race, education, body mass, hypertension, and diabetes, the multivariate-adjusted odds of large total and subcortical WMH volumes remained elevated. Finally, high normal UA increased the odds of having excessive ischemic burden four- to fivefold in adults ages 60 and older. CONCLUSIONS: These findings demonstrate that mildly elevated serum uric acid is associated with increased burden of cerebral ischemic pathology, particularly in older adults. We outline the potential pathogenesis of this association. A clinical trial of antihyperuricemic medication to treat or prevent chronic brain ischemia might be warranted.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalNeurology
Volume69
Issue number14
DOIs
StatePublished - Oct 2007

Fingerprint

Uric Acid
Brain Ischemia
Serum
Gout Suppressants
Sex Education
Vascular Diseases
Observational Studies
White Matter
Protons
Cross-Sectional Studies
Antioxidants
Logistic Models
Stroke
Odds Ratio
Clinical Trials
Pathology
Hypertension
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serum uric acid and brain ischemia in normal elderly adults. / Schretlen, David; Inscore, A. B.; Vannorsdall, Tracy; Kraut, Michael A; Pearlson, G. D.; Gordon, Barry; Jinnah, H. A.

In: Neurology, Vol. 69, No. 14, 10.2007, p. 1418-1423.

Research output: Contribution to journalArticle

Schretlen, David ; Inscore, A. B. ; Vannorsdall, Tracy ; Kraut, Michael A ; Pearlson, G. D. ; Gordon, Barry ; Jinnah, H. A. / Serum uric acid and brain ischemia in normal elderly adults. In: Neurology. 2007 ; Vol. 69, No. 14. pp. 1418-1423.
@article{c7df3b14979a4764868ef02c3a8ab67d,
title = "Serum uric acid and brain ischemia in normal elderly adults",
abstract = "BACKGROUND: Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults. METHOD: In this cross-sectional, observational study, we examined the relationship between serum UA and aggregate volume of white matter hyperintense (WMH) signals observed on proton density and T2-weighted brain MR images in a community sample of 177 adults ages 20 to 92. Using logistic regression, we tested whether participants with UA concentrations in the highest quartile of the sample-but still normal-would have increased WMH volumes. RESULTS: Compared with those with low to moderate levels, participants with high normal serum UA were more likely to fall in the highest quartile of WMH volume. The odds ratios (95{\%} CIs) of increased WMH were 2.6 (1.2 to 5.4) for total, 2.5 (1.2 to 5.1) for periventricular, and 2.8 (1.4 to 5.9) for subcortical WMH volume. After controlling for age, sex, race, education, body mass, hypertension, and diabetes, the multivariate-adjusted odds of large total and subcortical WMH volumes remained elevated. Finally, high normal UA increased the odds of having excessive ischemic burden four- to fivefold in adults ages 60 and older. CONCLUSIONS: These findings demonstrate that mildly elevated serum uric acid is associated with increased burden of cerebral ischemic pathology, particularly in older adults. We outline the potential pathogenesis of this association. A clinical trial of antihyperuricemic medication to treat or prevent chronic brain ischemia might be warranted.",
author = "David Schretlen and Inscore, {A. B.} and Tracy Vannorsdall and Kraut, {Michael A} and Pearlson, {G. D.} and Barry Gordon and Jinnah, {H. A.}",
year = "2007",
month = "10",
doi = "10.1212/01.wnl.0000277468.10236.f1",
language = "English (US)",
volume = "69",
pages = "1418--1423",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

TY - JOUR

T1 - Serum uric acid and brain ischemia in normal elderly adults

AU - Schretlen, David

AU - Inscore, A. B.

AU - Vannorsdall, Tracy

AU - Kraut, Michael A

AU - Pearlson, G. D.

AU - Gordon, Barry

AU - Jinnah, H. A.

PY - 2007/10

Y1 - 2007/10

N2 - BACKGROUND: Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults. METHOD: In this cross-sectional, observational study, we examined the relationship between serum UA and aggregate volume of white matter hyperintense (WMH) signals observed on proton density and T2-weighted brain MR images in a community sample of 177 adults ages 20 to 92. Using logistic regression, we tested whether participants with UA concentrations in the highest quartile of the sample-but still normal-would have increased WMH volumes. RESULTS: Compared with those with low to moderate levels, participants with high normal serum UA were more likely to fall in the highest quartile of WMH volume. The odds ratios (95% CIs) of increased WMH were 2.6 (1.2 to 5.4) for total, 2.5 (1.2 to 5.1) for periventricular, and 2.8 (1.4 to 5.9) for subcortical WMH volume. After controlling for age, sex, race, education, body mass, hypertension, and diabetes, the multivariate-adjusted odds of large total and subcortical WMH volumes remained elevated. Finally, high normal UA increased the odds of having excessive ischemic burden four- to fivefold in adults ages 60 and older. CONCLUSIONS: These findings demonstrate that mildly elevated serum uric acid is associated with increased burden of cerebral ischemic pathology, particularly in older adults. We outline the potential pathogenesis of this association. A clinical trial of antihyperuricemic medication to treat or prevent chronic brain ischemia might be warranted.

AB - BACKGROUND: Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults. METHOD: In this cross-sectional, observational study, we examined the relationship between serum UA and aggregate volume of white matter hyperintense (WMH) signals observed on proton density and T2-weighted brain MR images in a community sample of 177 adults ages 20 to 92. Using logistic regression, we tested whether participants with UA concentrations in the highest quartile of the sample-but still normal-would have increased WMH volumes. RESULTS: Compared with those with low to moderate levels, participants with high normal serum UA were more likely to fall in the highest quartile of WMH volume. The odds ratios (95% CIs) of increased WMH were 2.6 (1.2 to 5.4) for total, 2.5 (1.2 to 5.1) for periventricular, and 2.8 (1.4 to 5.9) for subcortical WMH volume. After controlling for age, sex, race, education, body mass, hypertension, and diabetes, the multivariate-adjusted odds of large total and subcortical WMH volumes remained elevated. Finally, high normal UA increased the odds of having excessive ischemic burden four- to fivefold in adults ages 60 and older. CONCLUSIONS: These findings demonstrate that mildly elevated serum uric acid is associated with increased burden of cerebral ischemic pathology, particularly in older adults. We outline the potential pathogenesis of this association. A clinical trial of antihyperuricemic medication to treat or prevent chronic brain ischemia might be warranted.

UR - http://www.scopus.com/inward/record.url?scp=34848872574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848872574&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000277468.10236.f1

DO - 10.1212/01.wnl.0000277468.10236.f1

M3 - Article

C2 - 17909154

AN - SCOPUS:34848872574

VL - 69

SP - 1418

EP - 1423

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 14

ER -