Serum therapy for cryptococcal meningitis

Morris A. Gordon, Arturo Casadevall

Research output: Contribution to journalComment/debatepeer-review

Abstract

Three patients were treated with combined amphotericin B and rabbit anticryptococcal antibody in the 1960s. Rabbitantibodywasadministered intravenously and waswentolerated.For each patient, administration of rabbit antibody resulted in the appearance of serum Cryptococcus neoformans agglutinins. For two patients the administration of rabbit antibody resulted in negative serum latex tests for cryptococcal antigen. This limited experience with adjunctive antibody therapy provides valuable precedents if antibody therapy is used again for treatment of human cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1477-1479
Number of pages3
JournalClinical Infectious Diseases
Volume21
Issue number6
DOIs
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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