Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Alicja Kalinowska-Łyszczarz, Sławomir Michalak, Mikołaj A. Pawlak, Jacek Losy, Wojciech Kozubski

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalJournal of Neuroimmunology
Volume300
DOIs
StatePublished - Nov 15 2016
Externally publishedYes

Keywords

  • Biomarkers
  • Human Vascular Cell Adhesion Molecule-1 (VCAM-1)
  • Multiple sclerosis
  • Neuromyelitis optica
  • Optic neuritis
  • Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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