Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Alicja Kalinowska-Łyszczarz; Sławomir Michalak; Mikołaj A. Pawlak; Jacek Losy; Wojciech Kozubski

doi:10.1016/j.jneuroim.2016.10.003

Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Alicja Kalinowska-Łyszczarz, Sławomir Michalak, Mikołaj A. Pawlak, Jacek Losy, Wojciech Kozubski

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.

Original language	English (US)
Pages (from-to)	11-14
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	300
DOIs	https://doi.org/10.1016/j.jneuroim.2016.10.003
State	Published - Nov 15 2016
Externally published	Yes

Keywords

Biomarkers
Human Vascular Cell Adhesion Molecule-1 (VCAM-1)
Multiple sclerosis
Neuromyelitis optica
Optic neuritis
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2016.10.003

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title = "Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis",

abstract = "Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.",

keywords = "Biomarkers, Human Vascular Cell Adhesion Molecule-1 (VCAM-1), Multiple sclerosis, Neuromyelitis optica, Optic neuritis, Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)",

author = "Alicja Kalinowska-{\L}yszczarz and S{\l}awomir Michalak and Pawlak, {Miko{\l}aj A.} and Jacek Losy and Wojciech Kozubski",

note = "Funding Information: Dr. Andrzej Styszynski from Department of Ophthalmology, Regional Hospital in Poznan, contributed to the study by kindly providing access to optic neuritis patients. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.jneuroim.2016.10.003",

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T1 - Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

AU - Kalinowska-Łyszczarz, Alicja

AU - Michalak, Sławomir

AU - Pawlak, Mikołaj A.

AU - Losy, Jacek

AU - Kozubski, Wojciech

N1 - Funding Information: Dr. Andrzej Styszynski from Department of Ophthalmology, Regional Hospital in Poznan, contributed to the study by kindly providing access to optic neuritis patients. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2016 Elsevier B.V.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (−) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.

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KW - Multiple sclerosis

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KW - Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

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ER -

Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis

Abstract

Keywords

ASJC Scopus subject areas

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