Serum Sickness After Treatment With Rabbit Antithymocyte Globulin in Kidney Transplant Recipients With Previous Rabbit Exposure

Raghavender Boothpur, Karen L. Hardinger, Rebecca M. Skelton, Brunilda Lluka, Matthew J. Koch, Brent W. Miller, Niraj M. Desai, Daniel C. Brennan

Research output: Contribution to journalArticle

Abstract

Serum sickness after rabbit antithymocyte globulin administration has a reported incidence of 7% to 27% in kidney transplant recipients. We describe 4 patients with previous exposure to rabbits who developed serum sickness after primary rabbit antithymocyte globulin induction. All patients presented with jaw pain. Three of 4 patients treated with plasmapheresis and steroids had prompt recovery, and 1 patient treated with steroids had slower recovery. We performed a telephone interview of 214 patients who contemporaneously underwent transplantation between November 2006 and July 2008 regarding rabbit exposure. More than half the patients had some type of previous rabbit exposure. There was a suggestion that patients with serum sickness were exposed more frequently to rabbits than those without. Jaw pain appears to be a hallmark symptom, and treatment with plasmapheresis and steroids relieves symptoms more rapidly than steroids alone.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume55
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Thymoglobulin
  • induction
  • kidney transplant
  • plasmapheresis
  • rabbit-ATG
  • serum sickness
  • treatment

ASJC Scopus subject areas

  • Nephrology

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