The levels of N acetyl neuraminic acid (sialic acid) in normal men and pre and post menopausal women were determined. Smoking, post menopausal estrogen therapy, oral contraceptives, and refreezing had no effects on sialic acid levels. Pre treatment values from patients with lung carcinoma showed markedly elevated levels of sialic acid (0.697 ± 0.149 μM/ml) as compared to those from normal controls (0.432 ± 0.067 μM/ml). The potential usefulness of sialic acid as a biological marker is discussed.
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