@article{23583e96dfaa4320a00fa5fbc5af4e42,
title = "Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue",
abstract = "The cytokine soluble CD23 (sCD23) acts as a B cell growth factor and is associated with Epstein-Barr virus (EBV) infection. To elucidate the role sCD23 might play in the pathogenesis of AIDS-related non-Hodgkin's lymphoma (AIDS NHL), 101 AIDS NHL patients from the Multicenter AIDS Cohort Study were studied. Serum sCD23 within 18 months prior to lymphoma diagnosis was measured for all patients and EBV in tumor tissue was ascertained for 49 patients. Tumor morphology and primary site were verified from pathology reports and tumor specimens. Bivariate tests and multivariate regression were employed to determine whether serum sCD23 correlated with tumor EBV, morphology, and primary site. Higher levels of serum sCD23 were associated with the absence of tumor EBV and with small noncleaved cell morphology. Thus, the serum sCD23 level does not appear to be mediated by EBV in these patients, but could be related to a pathogenetic mechanism of small noncleaved cell lymphoma.",
keywords = "AIDS, Epstein-Barr virus, Non-Hodgkin's lymphoma, sCD23",
author = "Schroeder, {Jennifer R.} and Saah, {Alfred J.} and Ambinder, {Richard F.} and Otoniel Martinez-Maza and {Crabb Breen}, Elizabeth and Daina Variakojis and Margolick, {Joseph B.} and Jacobson, {Lisa P.} and Rowe, {David T.} and Hoover, {Donald R.}",
note = "Funding Information: The Multicenter AIDS Cohort Study includes the following: Baltimore, The Johns Hopkins University School of Hygiene and Public Health, Joseph B. Margolick, Principal Investigator; Chicago, Howard Brown Health Center and Northwestern University Medical School, John P. Phair, Principal Investigator; Los Angeles, University of California, UCLA Schools of Public Health and Medicine, Roger Detels, Principal Investigator; Pittsburgh, University of Pittsburgh Graduate School of Public Health, Charles R. Rinaldo, Principal Investigator; Data Coordinating Center, The Johns Hopkins University School of Hygiene and Public Health, Alvaro Munoz, Principal Investigator. The MACS is funded by the National Institutes of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute and the Agency for Health Care Policy and Research: UOI-AI-35042, 5-M01-RR-00052 (GCRC), U01-AI-35043, U01-AI-37984; U01-AI-35039; U01-AI-35040; U01-AI-37613; U01-AI-35041. Additional support for this work was obtained from NIH (CA73475, T32AI07388) and from the Epidemiology Department of the Johns Hopkins School of Hygiene and Public Health (SPS Student Support).",
year = "1999",
month = dec,
doi = "10.1006/clim.1999.4793",
language = "English (US)",
volume = "93",
pages = "239--244",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "3",
}