Serum Protein Electrophoresis Patterns in Chronic Lymphocytic Leukemia: Clinical and Epidemiologic Correlations

Robin H. Miller, Martha S. Linet, Mark L Van Natta, Lee D. Mccaffrey, Richard L Humphrey

Research output: Contribution to journalArticle

Abstract

Serum protein electrophoresis (SPEP) data obtained at diagnosis were available for 98 of 342 patients with chronic lymphocytic leukemia (CLL) identified in a population-based case-control epidemiologic study. Patients tested with SPEP at diagnosis were significantly younger, more likely to have lymphadenopathy, and more likely to have had their conditions diagnosed at a university hospital than those not tested. Four categories of electrophoretic patterns were identified: normal (N=56), hypogammaglobulinemia (N=28), hypergammaglobulinemia (N=11), and monoclonal gammopathy (N=3). A higher proportion of those with hypergammaglobulinemia were black, and patients with hypergammaglobulinemia and monoclonal gammopathy were more likely to die within the first year following diagnosis than patients in the other SPEP groups. No association was found, however, between SPEP pattern and a clinical staging classification for CLL. These findings suggest that SPEP may be a useful adjunct in categorizing possible subtypes of CLL and developing future clinical staging classifications.

Original languageEnglish (US)
Pages (from-to)1614-1617
Number of pages4
JournalArchives of Internal Medicine
Volume147
Issue number9
DOIs
StatePublished - 1987

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B-Cell Chronic Lymphocytic Leukemia
Electrophoresis
Blood Proteins
Hypergammaglobulinemia
Paraproteinemias
Agammaglobulinemia
Case-Control Studies
Epidemiologic Studies
Population

ASJC Scopus subject areas

  • Internal Medicine

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Serum Protein Electrophoresis Patterns in Chronic Lymphocytic Leukemia : Clinical and Epidemiologic Correlations. / Miller, Robin H.; Linet, Martha S.; Van Natta, Mark L; Mccaffrey, Lee D.; Humphrey, Richard L.

In: Archives of Internal Medicine, Vol. 147, No. 9, 1987, p. 1614-1617.

Research output: Contribution to journalArticle

Miller, Robin H. ; Linet, Martha S. ; Van Natta, Mark L ; Mccaffrey, Lee D. ; Humphrey, Richard L. / Serum Protein Electrophoresis Patterns in Chronic Lymphocytic Leukemia : Clinical and Epidemiologic Correlations. In: Archives of Internal Medicine. 1987 ; Vol. 147, No. 9. pp. 1614-1617.
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