Serum Protein-Bound Carbohydrates for Following the Course of Disease in Patients With Metastatic Breast Carcinoma

T. Phillip Waalkes, John E. Mrochek, Stanley R. Dinsmore, Douglas C. Tormey

Research output: Contribution to journalArticlepeer-review

Abstract

Serum protein-bound carbohydrates, L-fucose, sialic acid, D-galactose, and D-mannose, were measured as potential biologic markers in patients with breast cancer with the use of high-resolution anion exchange separation in combination with a sensitive cerate oxidimetric fluorescence detector system. For 22 randomly selected patients with proved metastatic breast cancer, both L-fucose and sialic acid levels were above the normal range in 21 patients (95%). In contrast, o-mannose was increased in the sera of 9 patients (41%), and D-galactose in 6 (27%). By comparison, the level of carcinoembryonic antigen (CEA) was elevated in 14 patients (64%). The levels for serially determined serum protein-bound carbohydrates paralleled objective changes of response or progression in 5 patients with measurable disease. As might be expected, the degree and pattern of elevation for the individual carbohydrates varied for each patient studied. Combinations of serum protein-bound carbohydrates, particularly l- fucose and sialic acid, and, in addition, CEA, appear to have promise as potential biomarkers for following the course of the disease in patients with metastatic breast cancer.-J Natl Cancer Inst 61: 703-707, 1978.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalJournal of the National Cancer Institute
Volume61
Issue number3
DOIs
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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