Serum Prostate-Specific Antigen in a Community-Based Population of Healthy Men: Establishment of Age-Specific Reference Ranges

Joseph E. Oesterling, Steven J. Jacobsen, Christopher Chute, Harry A. Guess, Cynthia J. Girman, Laurei A. Panser, Michael M. Lieber

Research output: Contribution to journalArticle

Abstract

To define the characteristics of serum prostate-specific antigen (PSA) in a population of healthy men without clinically evident prostate cancer, but who are at risk for developing the malignancy. The influence of patient age and prostatic size on the serum PSA concentration was assessed in order to use PSA more appropriately to detect clinically significant prostate cancer at an early, potentially curable stage. Prospective, community-based study. Between December 1989 and March 1991, 2119 healthy men aged 40 to 79 years from Olmsted County, Minnesota, were entered into a prospective study to assess the natural history of benign prostatic hyperplasia. Of these, 537 (25%) were randomly chosen to participate in a detailed clinical examination that included a serum PSA determination (Tandem-R PSA assay), digital rectal examination, and transrectal ultrasonography. Four hundred seventy-one (88%) completed the prostatic evaluation and had no evidence of prostate cancer by any of these three diagnostic tests; these men formed the study population on which all analyses were performed. Serum PSA concentration, prostatic volume, and PSA density (serum PSA level/prostatic volume) as a function of patient age. The serum PSA concentration is correlated with patient age (r=.43; P

Original languageEnglish (US)
Pages (from-to)860-864
Number of pages5
JournalJournal of the American Medical Association
Volume270
Issue number7
DOIs
StatePublished - Aug 18 1993
Externally publishedYes

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Prostate-Specific Antigen
Reference Values
Serum
Population
Prostatic Neoplasms
Digital Rectal Examination
Prostatic Hyperplasia
Routine Diagnostic Tests
Ultrasonography
Prospective Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serum Prostate-Specific Antigen in a Community-Based Population of Healthy Men : Establishment of Age-Specific Reference Ranges. / Oesterling, Joseph E.; Jacobsen, Steven J.; Chute, Christopher; Guess, Harry A.; Girman, Cynthia J.; Panser, Laurei A.; Lieber, Michael M.

In: Journal of the American Medical Association, Vol. 270, No. 7, 18.08.1993, p. 860-864.

Research output: Contribution to journalArticle

Oesterling, Joseph E. ; Jacobsen, Steven J. ; Chute, Christopher ; Guess, Harry A. ; Girman, Cynthia J. ; Panser, Laurei A. ; Lieber, Michael M. / Serum Prostate-Specific Antigen in a Community-Based Population of Healthy Men : Establishment of Age-Specific Reference Ranges. In: Journal of the American Medical Association. 1993 ; Vol. 270, No. 7. pp. 860-864.
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