Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA)

Jason P. Linefsky, Kevin D. O'Brien, Michael Sachs, Ronit Katz, John Eng, Erin Donnelly Michos, Matthew J. Budoff, Ian De Boer, Bryan Kestenbaum

Research output: Contribution to journalArticle

Abstract

Objectives: This study sought to investigate associations of phosphate metabolism biomarkers with aortic valve calcification (AVC). Background: Calcific aortic valve disease (CAVD) is a common progressive condition that involves inflammatory and calcification mediators. Currently there are no effective medical treatments, but mineral metabolism pathways may be important in the development and progression of disease. Methods: We examined associations of phosphate metabolism biomarkers, including serum phosphate, urine phosphate, parathyroid hormone (PTH) and serum fibroblast growth factor (FGF)-23, with CT-assessed AVC at study baseline and in short-term follow-up in 6814 participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Results: At baseline, AVC prevalence was 13.2%. Higher serum phosphate levels were associated with significantly greater AVC prevalence (relative risk 1.3 per 1mg/dL increment, 95% confidence incidence: 1.1 to 1.5, p

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalAtherosclerosis
Volume233
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Atherosclerosis
Phosphates
Serum
Biomarkers
Aortic Diseases
Parathyroid Hormone
Aortic Valve
Minerals
Disease Progression
Calcification of Aortic Valve
Urine
Incidence

Keywords

  • Aortic valve
  • Calcification
  • Phosphate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA). / Linefsky, Jason P.; O'Brien, Kevin D.; Sachs, Michael; Katz, Ronit; Eng, John; Michos, Erin Donnelly; Budoff, Matthew J.; De Boer, Ian; Kestenbaum, Bryan.

In: Atherosclerosis, Vol. 233, No. 2, 2014, p. 331-337.

Research output: Contribution to journalArticle

Linefsky, Jason P. ; O'Brien, Kevin D. ; Sachs, Michael ; Katz, Ronit ; Eng, John ; Michos, Erin Donnelly ; Budoff, Matthew J. ; De Boer, Ian ; Kestenbaum, Bryan. / Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA). In: Atherosclerosis. 2014 ; Vol. 233, No. 2. pp. 331-337.
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AU - Eng, John

AU - Michos, Erin Donnelly

AU - Budoff, Matthew J.

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AU - Kestenbaum, Bryan

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