Serum Phosphate and the Risk of New-Onset Hyperuricemia in Hypertensive Patients

Jingjing Cao, Jingping Zhang, Qinqin Li, Chongfei Jiang, Yun Song, Chengzhang Liu, Lishun Liu, Binyan Wang, Jianping Li, Yan Zhang, Yimin Cui, Yong Huo, Xiaobin Wang, Genfu Tang, Xiping Xu, Xianhui Qin

Research output: Contribution to journalArticle

Abstract

The relationship of serum phosphate and new-onset hyperuricemia remains uncertain. We aimed to evaluate the relationship of serum phosphate with the risk of new-onset hyperuricemia, and to examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric Acid substudy of the CSPPT (China Stroke Primary Prevention Trial). A total of 10 612 participants with normal uric acid levels (<357 μmol/L [6 mg/dL]) at baseline were included in the current study. The primary outcome was new-onset hyperuricemia, which was defined as a uric acid concentration ≥417 μmol/L (7 mg/dL) in men or ≥357 μmol/L (6 mg/dL) in women. During a median follow-up of 4.4 years, 1663 (15.7%) participants developed new-onset hyperuricemia. Overall, there was a significant inverse association between serum phosphate and the risk of new-onset hyperuricemia (per SD increment; odds ratio, 0.71; 95% CI, 0.66-0.76). When serum phosphate was assessed as quartiles, a significantly lower risk of new-onset hyperuricemia was found in participants in quartile 4 (≥1.4 mmol/L; odds ratio, 0.48; 95% CI, 0.40-0.57) compared with those in quartile 1 (<1.2 mmol/L). Similar results were found in males and females. In summary, there was an inverse association between serum phosphate and the risk of new-onset hyperuricemia in hypertensive adults.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalHypertension
Volume74
Issue number1
DOIs
StatePublished - Jul 1 2019

Keywords

  • homocysteine
  • hypertension
  • hyperuricemia
  • phosphates
  • uric acid

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Cao, J., Zhang, J., Li, Q., Jiang, C., Song, Y., Liu, C., Liu, L., Wang, B., Li, J., Zhang, Y., Cui, Y., Huo, Y., Wang, X., Tang, G., Xu, X., & Qin, X. (2019). Serum Phosphate and the Risk of New-Onset Hyperuricemia in Hypertensive Patients. Hypertension, 74(1), 102-110. https://doi.org/10.1161/HYPERTENSIONAHA.119.12633