Serum pentraxin-3 levels at 11 to 14 weeks' gestation: association with maternal and placental characteristics

Ahmet Baschat, Tania L. Kasdaglis, Graham W. Aberdeen, Ozhan M. Turan, Jerome L. Kopelman, Robert Atlas, Chuka Jenkins, Miriam Blitzer, Christopher R. Harman

Research output: Contribution to journalArticle

Abstract

Objective: Pentraxin (PTX)-3 is an inflammatory molecule that may be increased in the first trimester in pregnancies with subsequent preeclampsia. We measured first-trimester serum PTX-3 and correlated levels with maternal/placental factors related to placental development. Study Design: Prospectively enrolled women had ultrasound, physical examination, and blood draw at 11-14 weeks. PTX-3 determined by enzyme-linked immunosorbent assay was related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine, and uterine/umbilical artery Doppler pulsatility index (PI). Results: In 111 patients PTX-3 levels ranged from 0.2-13.8 ng/mL. Spearman correlation between PTX-3 and gestational age (rho = 0.096), maternal age (rho = -0.049), BMI (rho = -0.07), MAP (rho = -0.085), mean uterine artery PI (rho = 0.150), and umbilical artery PI (rho = -0.021) was nonsignificant (all P > .05). Similarly, PTX-3 distribution was unaffected by smoking/caffeine use, BMI >30, MAP >100 mm Hg, or uterine artery notching (P > .05 for all). Conclusion: First-trimester PTX-3 is unrelated to maternal characteristics and placental Doppler.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume201
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Mothers
Arterial Pressure
Pregnancy
Uterine Artery
Serum
First Pregnancy Trimester
Umbilical Arteries
Body Mass Index
Maternal Age
Caffeine
Smoking
Placentation
Pre-Eclampsia
Parity
PTX3 protein
Gestational Age
Physical Examination
Enzyme-Linked Immunosorbent Assay

Keywords

  • fetal Doppler
  • maternal Doppler
  • pentraxin-3
  • placenta

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Serum pentraxin-3 levels at 11 to 14 weeks' gestation : association with maternal and placental characteristics. / Baschat, Ahmet; Kasdaglis, Tania L.; Aberdeen, Graham W.; Turan, Ozhan M.; Kopelman, Jerome L.; Atlas, Robert; Jenkins, Chuka; Blitzer, Miriam; Harman, Christopher R.

In: American Journal of Obstetrics and Gynecology, Vol. 201, No. 3, 09.2009.

Research output: Contribution to journalArticle

Baschat, Ahmet ; Kasdaglis, Tania L. ; Aberdeen, Graham W. ; Turan, Ozhan M. ; Kopelman, Jerome L. ; Atlas, Robert ; Jenkins, Chuka ; Blitzer, Miriam ; Harman, Christopher R. / Serum pentraxin-3 levels at 11 to 14 weeks' gestation : association with maternal and placental characteristics. In: American Journal of Obstetrics and Gynecology. 2009 ; Vol. 201, No. 3.
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AU - Turan, Ozhan M.

AU - Kopelman, Jerome L.

AU - Atlas, Robert

AU - Jenkins, Chuka

AU - Blitzer, Miriam

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