TY - JOUR
T1 - Serum pentraxin-3 levels at 11 to 14 weeks' gestation
T2 - association with maternal and placental characteristics
AU - Baschat, Ahmet A.
AU - Kasdaglis, Tania L.
AU - Aberdeen, Graham W.
AU - Turan, Ozhan M.
AU - Kopelman, Jerome L.
AU - Atlas, Robert
AU - Jenkins, Chuka
AU - Blitzer, Miriam
AU - Harman, Christopher R.
N1 - Funding Information:
This study was supported by the Center for Advanced Fetal Care Foundation, University of Maryland School of Medicine.
PY - 2009/9
Y1 - 2009/9
N2 - Objective: Pentraxin (PTX)-3 is an inflammatory molecule that may be increased in the first trimester in pregnancies with subsequent preeclampsia. We measured first-trimester serum PTX-3 and correlated levels with maternal/placental factors related to placental development. Study Design: Prospectively enrolled women had ultrasound, physical examination, and blood draw at 11-14 weeks. PTX-3 determined by enzyme-linked immunosorbent assay was related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine, and uterine/umbilical artery Doppler pulsatility index (PI). Results: In 111 patients PTX-3 levels ranged from 0.2-13.8 ng/mL. Spearman correlation between PTX-3 and gestational age (rho = 0.096), maternal age (rho = -0.049), BMI (rho = -0.07), MAP (rho = -0.085), mean uterine artery PI (rho = 0.150), and umbilical artery PI (rho = -0.021) was nonsignificant (all P > .05). Similarly, PTX-3 distribution was unaffected by smoking/caffeine use, BMI >30, MAP >100 mm Hg, or uterine artery notching (P > .05 for all). Conclusion: First-trimester PTX-3 is unrelated to maternal characteristics and placental Doppler.
AB - Objective: Pentraxin (PTX)-3 is an inflammatory molecule that may be increased in the first trimester in pregnancies with subsequent preeclampsia. We measured first-trimester serum PTX-3 and correlated levels with maternal/placental factors related to placental development. Study Design: Prospectively enrolled women had ultrasound, physical examination, and blood draw at 11-14 weeks. PTX-3 determined by enzyme-linked immunosorbent assay was related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine, and uterine/umbilical artery Doppler pulsatility index (PI). Results: In 111 patients PTX-3 levels ranged from 0.2-13.8 ng/mL. Spearman correlation between PTX-3 and gestational age (rho = 0.096), maternal age (rho = -0.049), BMI (rho = -0.07), MAP (rho = -0.085), mean uterine artery PI (rho = 0.150), and umbilical artery PI (rho = -0.021) was nonsignificant (all P > .05). Similarly, PTX-3 distribution was unaffected by smoking/caffeine use, BMI >30, MAP >100 mm Hg, or uterine artery notching (P > .05 for all). Conclusion: First-trimester PTX-3 is unrelated to maternal characteristics and placental Doppler.
KW - fetal Doppler
KW - maternal Doppler
KW - pentraxin-3
KW - placenta
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U2 - 10.1016/j.ajog.2009.05.039
DO - 10.1016/j.ajog.2009.05.039
M3 - Article
C2 - 19631929
AN - SCOPUS:69349103853
SN - 0002-9378
VL - 201
SP - 298.e1-298.e6
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -