Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease

Don D. Sin, Bruce E. Miller, Annelyse Duvoix, S. F Paul Man, Xuekui Zhang, Edwin K. Silverman, John E. Connett, Nicholas A. Anthonisen, Robert A Wise, Donald Tashkin, Bartolome R. Celli, Lisa D. Edwards, Nicholas Locantore, William MacNee, Ruth Tal-Singer, David A. Lomas

Research output: Contribution to journalArticle

Abstract

Rationale: There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. Objectives: To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. Methods: PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Measurements and Main Results: Serum PARC/CCL-18 levels were higher in subjects withCOPDthan in smokers or lifetimenonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P <0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Conclusions: Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552).

Original languageEnglish (US)
Pages (from-to)1187-1192
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume183
Issue number9
DOIs
StatePublished - May 1 2011

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Chronic Obstructive Pulmonary Disease
Health
Serum
Lung
Biomarkers
Chemokines
Mortality
Hospitalization
Prednisolone
Cohort Studies
Clinical Trials
Proteins

Keywords

  • Biomarker
  • Chemokine
  • Chronic obstructive pulmonary disease
  • PARC/CCL-18

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Sin, D. D., Miller, B. E., Duvoix, A., Man, S. F. P., Zhang, X., Silverman, E. K., ... Lomas, D. A. (2011). Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 183(9), 1187-1192. https://doi.org/10.1164/rccm.201008-1220OC

Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease. / Sin, Don D.; Miller, Bruce E.; Duvoix, Annelyse; Man, S. F Paul; Zhang, Xuekui; Silverman, Edwin K.; Connett, John E.; Anthonisen, Nicholas A.; Wise, Robert A; Tashkin, Donald; Celli, Bartolome R.; Edwards, Lisa D.; Locantore, Nicholas; MacNee, William; Tal-Singer, Ruth; Lomas, David A.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 183, No. 9, 01.05.2011, p. 1187-1192.

Research output: Contribution to journalArticle

Sin, DD, Miller, BE, Duvoix, A, Man, SFP, Zhang, X, Silverman, EK, Connett, JE, Anthonisen, NA, Wise, RA, Tashkin, D, Celli, BR, Edwards, LD, Locantore, N, MacNee, W, Tal-Singer, R & Lomas, DA 2011, 'Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 9, pp. 1187-1192. https://doi.org/10.1164/rccm.201008-1220OC
Sin, Don D. ; Miller, Bruce E. ; Duvoix, Annelyse ; Man, S. F Paul ; Zhang, Xuekui ; Silverman, Edwin K. ; Connett, John E. ; Anthonisen, Nicholas A. ; Wise, Robert A ; Tashkin, Donald ; Celli, Bartolome R. ; Edwards, Lisa D. ; Locantore, Nicholas ; MacNee, William ; Tal-Singer, Ruth ; Lomas, David A. / Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease. In: American Journal of Respiratory and Critical Care Medicine. 2011 ; Vol. 183, No. 9. pp. 1187-1192.
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abstract = "Rationale: There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. Objectives: To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. Methods: PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Measurements and Main Results: Serum PARC/CCL-18 levels were higher in subjects withCOPDthan in smokers or lifetimenonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P <0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Conclusions: Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552).",
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AU - Zhang, Xuekui

AU - Silverman, Edwin K.

AU - Connett, John E.

AU - Anthonisen, Nicholas A.

AU - Wise, Robert A

AU - Tashkin, Donald

AU - Celli, Bartolome R.

AU - Edwards, Lisa D.

AU - Locantore, Nicholas

AU - MacNee, William

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AU - Lomas, David A.

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N2 - Rationale: There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. Objectives: To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. Methods: PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Measurements and Main Results: Serum PARC/CCL-18 levels were higher in subjects withCOPDthan in smokers or lifetimenonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P <0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Conclusions: Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552).

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