Serum oxytetracycline concentrations in African elephant (loxodonta africana) calves after long-acting formulation injection

M. Bush, M. K. Stoskopf, J. P. Raath, M. G. Papich

Research output: Contribution to journalArticlepeer-review

Abstract

Serum oxytetracycline pharmacokinetics were studied in 18 African elephant (Loxodonta africana) calves. Each elephant received separate injections of oxytetracycline at approximately 18 mg/kg i.m. and 8 mg/kg i.v. in a cross-over study. Blood samples were drawn at 0, 24, 48, 72, and 96 hr postinjection. An additional sample was drawn 110 hr before the animals were reinjected in the cross-over study and a final blood sample was drawn 48 hr after the second dose. No lameness or stiffness was observed following i.m. injections. Serum oxytetracycline concentrations >0.5 μg/ml were present 48 hr after initial dosing for all elephants (i.m., i.v., high or low dosage). Only elephants given the high i.m. dosage (18 mg/kg) maintained levels >0.5 μg/ml 72 hr postinjection. No significant difference in serum oxytetracycline concentration with time was observed between the groups given different i.v. dosages. These studies demonstrated that quantifiable serum oxytetracycline concentrations can be maintained in young African elephants with a low-dosage multidose i.m. regimen.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalJournal of Zoo and Wildlife Medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2000

Keywords

  • African elephant
  • Loxodonta africana
  • Oxytetracycline
  • Pharmacokinetics
  • Serum drug concentrations

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Serum oxytetracycline concentrations in African elephant (loxodonta africana) calves after long-acting formulation injection'. Together they form a unique fingerprint.

Cite this