Serum opsonic activity in infants with sickle-cell disease immunized with pneumococcal polysaccharide protein conjugate vaccine

A. Nowak-Wegrzyn, J. A. Winkelstein, A. J. Swift, H. M. Lederman, J. Gootenberg, G. Dover, K. O'Brien, M. Santosham, S. Snader, B. Stover, K. Hall, S. Panny, S. Ross, K. M. Hoffman, F. M. Kopack, J. T. Nold, P. S. Shelton, R. Luddy, J. Marascuilo, A. EskenaziK. Sawyer, A. Kimura, F. Malinoski

Research output: Contribution to journalArticle

Abstract

Pneumococcal infections are an important cause of morbidity and mortality in children with sickle-cell disease (SCD). Pneumococcal conjugate vaccines (PCVs) are immunogenic in healthy infants <2 years of age but have not been evaluated in young children with SCD. Infants with SCD were immunized with a 7-valent PCV (Wyeth-Lederle Vaccines and Pediatrics) at 2, 4, and 6 months of age. A booster dose of 23-valent pneumococcal polysaccharide vaccine (PPV; Pnu-Immune) was administered at 24 months of age. Antipneumococcal type 6B and 14 serum opsonic activity was measured to assess the biologic function of the antibody. Following the administration of three doses of PCV, opsonic activity against serotype 6B increased from 4.8% at 2 months to 33.5% at 7 months, with a subsequent decline to 8.1% at 12 months and 7.5% at 24 months and with an increase to 30.7% at 25 months after administration of a booster dose of PPV. Similar trends were seen with serotype 14 (opsonic activities were 9.4% at 2 months, 24.9% at 7 months, 16.5% at 12 months, and 12.6% at 24 months, and the opsonic activity was 27.3% 1 month after the administration of PPV). Serum opsonic activity correlated with antibody levels for both serotypes. PCV induces serum opsonic activity in infants with SCD. Antipneumococcal serum opsonic activity correlates with antibody levels.

Original languageEnglish (US)
Pages (from-to)788-793
Number of pages6
JournalClinical and diagnostic laboratory immunology
Volume7
Issue number5
DOIs
StatePublished - Sep 26 2000

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

Cite this

Nowak-Wegrzyn, A., Winkelstein, J. A., Swift, A. J., Lederman, H. M., Gootenberg, J., Dover, G., O'Brien, K., Santosham, M., Snader, S., Stover, B., Hall, K., Panny, S., Ross, S., Hoffman, K. M., Kopack, F. M., Nold, J. T., Shelton, P. S., Luddy, R., Marascuilo, J., ... Malinoski, F. (2000). Serum opsonic activity in infants with sickle-cell disease immunized with pneumococcal polysaccharide protein conjugate vaccine. Clinical and diagnostic laboratory immunology, 7(5), 788-793. https://doi.org/10.1128/CDLI.7.5.788-793.2000