Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children

B. D. Kirkpatrick, C. D. Huston, D. Wagner, F. Noel, P. Rouzier, J. W. Pape, G. Bois, C. J. Larsson, W. K. Alston, K. Tenney, C. Powden, J. P. O'Neill, Cynthia Louise Sears

Research output: Contribution to journalArticle

Abstract

Background. Mannose-binding lectin (MBL) is a component of the innate immune response and binds microbial surfaces through carbohydrate recognition domains. MBL deficiency may contribute to susceptibility to a variety of infectious diseases, particularly in young children. MBL binds to the Cryptosporidium sporozoite and may be important in resistance to cryptosporidiosis. Methods. We studied the association of serum MBL levels and cryptosporidiosis in a case-control study of young Haitian children with cryptosporidiosis versus children who were control subjects. Results. Ninety-nine children were enrolled, as follows: 49 children with cryptosporidiosis, 41 healthy controls, and 9 children with diarrhea from other causes. Case children were more malnourished than controls, and 49% had persistent or chronic diarrhea. At enrollment, mean serum MBL levels were markedly lower in children with cryptosporidiosis (P = .002), as was the number of children with an MBL deficiency of ≤70 ng/mL (P = .005). In multivariate analysis, the association of cryptosporidiosis and MBL deficiency persisted (P = .002; adjusted odds ratio, 22.4), as did the association of cryptosporidiosis with general malnutrition. The subset of children with cryptosporidiosis and MBL deficiency were more likely to be male (P = .025). Conclusions. MBL may be an important component of innate immune protection against Cryptosporidium infection in young children. Additional studies are necessary to determine whether MBL intestinal losses, deficient epithelial expression, and/or genetic polymorphisms in the MBI gene contribute to MBL deficiency in cryptosporidiosis and other enteric infections in young children.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalClinical Infectious Diseases
Volume43
Issue number3
DOIs
StatePublished - Aug 1 2006

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Cryptosporidiosis
Mannose-Binding Lectin
Serum
Cryptosporidium
Mannose-Binding Protein Deficiency
Diarrhea
Sporozoites
Genetic Polymorphisms
Infection
Innate Immunity
Malnutrition
Communicable Diseases
Case-Control Studies

ASJC Scopus subject areas

  • Immunology

Cite this

Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. / Kirkpatrick, B. D.; Huston, C. D.; Wagner, D.; Noel, F.; Rouzier, P.; Pape, J. W.; Bois, G.; Larsson, C. J.; Alston, W. K.; Tenney, K.; Powden, C.; O'Neill, J. P.; Sears, Cynthia Louise.

In: Clinical Infectious Diseases, Vol. 43, No. 3, 01.08.2006, p. 289-294.

Research output: Contribution to journalArticle

Kirkpatrick, BD, Huston, CD, Wagner, D, Noel, F, Rouzier, P, Pape, JW, Bois, G, Larsson, CJ, Alston, WK, Tenney, K, Powden, C, O'Neill, JP & Sears, CL 2006, 'Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children', Clinical Infectious Diseases, vol. 43, no. 3, pp. 289-294. https://doi.org/10.1086/505396
Kirkpatrick, B. D. ; Huston, C. D. ; Wagner, D. ; Noel, F. ; Rouzier, P. ; Pape, J. W. ; Bois, G. ; Larsson, C. J. ; Alston, W. K. ; Tenney, K. ; Powden, C. ; O'Neill, J. P. ; Sears, Cynthia Louise. / Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. In: Clinical Infectious Diseases. 2006 ; Vol. 43, No. 3. pp. 289-294.
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abstract = "Background. Mannose-binding lectin (MBL) is a component of the innate immune response and binds microbial surfaces through carbohydrate recognition domains. MBL deficiency may contribute to susceptibility to a variety of infectious diseases, particularly in young children. MBL binds to the Cryptosporidium sporozoite and may be important in resistance to cryptosporidiosis. Methods. We studied the association of serum MBL levels and cryptosporidiosis in a case-control study of young Haitian children with cryptosporidiosis versus children who were control subjects. Results. Ninety-nine children were enrolled, as follows: 49 children with cryptosporidiosis, 41 healthy controls, and 9 children with diarrhea from other causes. Case children were more malnourished than controls, and 49{\%} had persistent or chronic diarrhea. At enrollment, mean serum MBL levels were markedly lower in children with cryptosporidiosis (P = .002), as was the number of children with an MBL deficiency of ≤70 ng/mL (P = .005). In multivariate analysis, the association of cryptosporidiosis and MBL deficiency persisted (P = .002; adjusted odds ratio, 22.4), as did the association of cryptosporidiosis with general malnutrition. The subset of children with cryptosporidiosis and MBL deficiency were more likely to be male (P = .025). Conclusions. MBL may be an important component of innate immune protection against Cryptosporidium infection in young children. Additional studies are necessary to determine whether MBL intestinal losses, deficient epithelial expression, and/or genetic polymorphisms in the MBI gene contribute to MBL deficiency in cryptosporidiosis and other enteric infections in young children.",
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T1 - Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children

AU - Kirkpatrick, B. D.

AU - Huston, C. D.

AU - Wagner, D.

AU - Noel, F.

AU - Rouzier, P.

AU - Pape, J. W.

AU - Bois, G.

AU - Larsson, C. J.

AU - Alston, W. K.

AU - Tenney, K.

AU - Powden, C.

AU - O'Neill, J. P.

AU - Sears, Cynthia Louise

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Background. Mannose-binding lectin (MBL) is a component of the innate immune response and binds microbial surfaces through carbohydrate recognition domains. MBL deficiency may contribute to susceptibility to a variety of infectious diseases, particularly in young children. MBL binds to the Cryptosporidium sporozoite and may be important in resistance to cryptosporidiosis. Methods. We studied the association of serum MBL levels and cryptosporidiosis in a case-control study of young Haitian children with cryptosporidiosis versus children who were control subjects. Results. Ninety-nine children were enrolled, as follows: 49 children with cryptosporidiosis, 41 healthy controls, and 9 children with diarrhea from other causes. Case children were more malnourished than controls, and 49% had persistent or chronic diarrhea. At enrollment, mean serum MBL levels were markedly lower in children with cryptosporidiosis (P = .002), as was the number of children with an MBL deficiency of ≤70 ng/mL (P = .005). In multivariate analysis, the association of cryptosporidiosis and MBL deficiency persisted (P = .002; adjusted odds ratio, 22.4), as did the association of cryptosporidiosis with general malnutrition. The subset of children with cryptosporidiosis and MBL deficiency were more likely to be male (P = .025). Conclusions. MBL may be an important component of innate immune protection against Cryptosporidium infection in young children. Additional studies are necessary to determine whether MBL intestinal losses, deficient epithelial expression, and/or genetic polymorphisms in the MBI gene contribute to MBL deficiency in cryptosporidiosis and other enteric infections in young children.

AB - Background. Mannose-binding lectin (MBL) is a component of the innate immune response and binds microbial surfaces through carbohydrate recognition domains. MBL deficiency may contribute to susceptibility to a variety of infectious diseases, particularly in young children. MBL binds to the Cryptosporidium sporozoite and may be important in resistance to cryptosporidiosis. Methods. We studied the association of serum MBL levels and cryptosporidiosis in a case-control study of young Haitian children with cryptosporidiosis versus children who were control subjects. Results. Ninety-nine children were enrolled, as follows: 49 children with cryptosporidiosis, 41 healthy controls, and 9 children with diarrhea from other causes. Case children were more malnourished than controls, and 49% had persistent or chronic diarrhea. At enrollment, mean serum MBL levels were markedly lower in children with cryptosporidiosis (P = .002), as was the number of children with an MBL deficiency of ≤70 ng/mL (P = .005). In multivariate analysis, the association of cryptosporidiosis and MBL deficiency persisted (P = .002; adjusted odds ratio, 22.4), as did the association of cryptosporidiosis with general malnutrition. The subset of children with cryptosporidiosis and MBL deficiency were more likely to be male (P = .025). Conclusions. MBL may be an important component of innate immune protection against Cryptosporidium infection in young children. Additional studies are necessary to determine whether MBL intestinal losses, deficient epithelial expression, and/or genetic polymorphisms in the MBI gene contribute to MBL deficiency in cryptosporidiosis and other enteric infections in young children.

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DO - 10.1086/505396

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