Abstract
Sixteen cycles in 14 normally menstruating women, stimulated with human menopausal gonadotropin in order to recruit more than one follicle for a successful in vitro fertilization process, were adequately monitored to identify the appearance of the spontaneous luteinizing hormone (LH) surge. Daily serum LH determinations, increased to every 4 hours in the presumptive preovulatory period, showed that in these women the endogenous estrogen-triggered LH midcycle peak did not occur at the expected time. It is hypothesized that the mechanism responsible for this suppression is a negative feedback mediated by an increased circulating protein with an inhibin-like action.
Original language | English (US) |
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Pages (from-to) | 742-747 |
Number of pages | 6 |
Journal | Fertility and sterility |
Volume | 40 |
Issue number | 6 |
DOIs | |
State | Published - 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology